Sergey Y. Vakhrushev

The paper shows that GALA, a process relocating GALNTs to the ER, enables co-translational O-glycosylation in pancreatic cancer, expanding the O-glycoproteome and promoting tumor growth.

This study investigates the role of GOLPH3 in Golgi retention and trafficking, showing its regulation by S-acylation and its impact on glycosylation and development.

The paper shows that O-glycans in LRP1's ligand-binding domains differentially modulate uptake of tau and amyloid beta, but not RAP or ApoE.

The paper develops an MS-based workflow to detect Glu/Asp-ADPr modifications, identifies over 600 sites in cytokine-stimulated cells, and reveals residue-specific ADPr dynamics in immune signaling.

This study investigates how O-mannose glycosylations on E-cadherin affect its protein interactions, showing O-Man-dependent changes in CDH1 associations with CDH3 and other proteins.

This study determines the cryo-EM structure of human TMEM260, revealing its mechanism for O-mannosylation of key receptors and providing insights into related congenital disorders.

The paper identifies O-mannosylation and protein maturation as therapeutic targets in BRAF fusion oncogenesis by showing their necessity for fusion-induced transformation.

This study shows that loss of Galnt2 in mice leads to neurological symptoms similar to GALNT2-CDG and identifies O-glycosylation changes in the brain.

The paper maps O-Man glycoproteins in human cells and identifies substrate specificities of O-Man glycosylation pathways.

The paper maps O-glycosylation sites on SARS-CoV-2 spike protein produced in insect and human cells, identifying 25 sites with distinct patterns between ectodomains and RBD.