AAVs Targeting Human Carbonic Anhydrase IV Enhance Gene Delivery to the Brain
Changfan Lin, Xinhong Chen, Jonathan D. Hoang, Fiona Ristic, Yujie Fan, Seongmin Jang, Jin Hyung Alex Chung, Erin E. Sullivan, Tomasz Gawda, Bill Kavvathas, Irene Tran, Yitong Li, Andrew D. Steele, Timothy F. Shay, Viviana Gradinaru
This study engineers AAVs targeting human carbonic anhydrase IV to enhance brain gene delivery, finding that optimized variants achieve 100-fold greater transduction than AAV9.
Cell Reports · Oct 31, 2025Peer-reviewedBioengineering