Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation
Kevin C.L. Cheng, Jennifer M. Frost, Francisco Jose Sanchez-Luque, Marta García-Cañadas, Darren Taylor, Wan Rou Yang, Branavy Irayanar, Swetha Sampath, Hemalvi Patani, Karl Agger, Kristian Helin, Gabriella Ficz, Kathleen H. Burns, Adam D. Ewing, Jose Luis Garcia-Perez, Miguel Ramos Branco
This study shows that vitamin C increases young LINE-1 element expression in mouse ESCs through H3K9me3 demethylation by KDM4A/C, without increasing somatic insertion rates.
Epigenetics & Chromatin · Oct 16, 2023Peer-reviewedGenetics