Darren Taylor

This study shows that vitamin C increases young LINE-1 element expression in mouse ESCs through H3K9me3 demethylation by KDM4A/C, without increasing somatic insertion rates.

The paper develops a method to generate locus-specific chromatin profiles at transposable elements using HiChIP and PAtChER, revealing epigenetic variation in young TEs in mouse and human cells.

The paper evaluates the role of transposable elements as enhancers in mouse embryonic and trophoblast stem cells using bioinformatics and genetic editing, finding that only a minority significantly regulate gene expression.