Jose Luis Garcia-Perez

This study shows that DGCR8 haploinsufficiency in human pluripotent cells causes RNA dysregulation and pluripotency defects, with rescue by primate-specific miRNAs.

The paper shows HeLa strains differ in Alu retrotransposition efficiency, with distinct mechanisms for SINE RNA mobilization involving ORF2p.

This study shows that vitamin C increases young LINE-1 element expression in mouse ESCs through H3K9me3 demethylation by KDM4A/C, without increasing somatic insertion rates.

The paper reanalyzes single-cell transcriptomic data and in situ stains to reveal the presence of a transcriptomically homologous inner cell mass in human blastocysts, highlighting unique developmental and evolutionary features.

This study shows LINE-1 retrotransposition occurs in human pre-implantation embryos and extraembryonic tissues, impacting gene expression and potentially contributing to genomic variation.

This study identifies human-specific non-LTR retrotransposon insertions and shows their association with gene expression changes and phenotypic evolution in humans.

This study shows that TEX19.1 restricts L1 retrotransposon mobilisation in mouse embryonic stem cells by promoting the degradation of L1-ORF1p.