Francisco Jose Sanchez-Luque

This study shows that DGCR8 haploinsufficiency in human pluripotent cells causes RNA dysregulation and pluripotency defects, with rescue by primate-specific miRNAs.

This study shows that vitamin C increases young LINE-1 element expression in mouse ESCs through H3K9me3 demethylation by KDM4A/C, without increasing somatic insertion rates.

The paper investigates how L1 retrotransposition potential declines with age through methylation changes and promoter shortening in mice.

The paper identifies retrotransposon insertions as the main source of mutations in mouse induced pluripotent stem cells, showing hypomethylation of LINE-1 elements and their impact on gene regulation.

The paper shows that SOX6 activates LINE-1 retrotransposons in PV+ interneurons, leading to increased morphological complexity through a novel CAPS2 isoform.

The paper uses long-read sequencing to investigate SARS-CoV-2 integration into the human genome and finds no evidence of such integration in infected cells.

This study uses nanopore sequencing and the TLDR tool to profile CpG methylation of transposable elements in human tissues and tumors.

This study shows LINE-1 retrotransposition occurs in human pre-implantation embryos and extraembryonic tissues, impacting gene expression and potentially contributing to genomic variation.