Author

Brendan M. Smalec

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

L. Stirling ChurchmaniD· 3 shared Autum R. Baxter‐KoenigsiD· 2 shared Karine ChoquetiD· 2 shared Albert XuiD· 1 shared Becky Xu Hua FuiD· 1 shared Chantal K. GuegleriD· 1 shared Christian BrioniD· 1 shared Emma R. WestiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMolecular Biology

L. Stirling ChurchmanORCID

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3 papers

Recent·Most cited

GenomicsMolecular CellPeer-reviewedJul 1, 2024

Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle

Robert Ietswaart, Brendan M. Smalec, Albert Xu…·L. Stirling Churchman

The paper quantifies RNA flow across subcellular compartments using TimeLapse-seq and identifies factors influencing mRNA life cycles.

82 citationstop 1%

humanbulk RNA-seq

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Molecular BiologyNature Structural & Molecular BiologyPeer-reviewedJul 13, 2023

Pre-mRNA splicing order is predetermined and maintains splicing fidelity across multi-intronic transcripts

Karine Choquet, Autum R. Baxter‐Koenigs, Sarah-Luisa Dülk…·L. Stirling Churchman

The paper shows that pre-mRNA splicing order in human cells is largely predetermined and conserved across cell types and differentiation stages, ensuring splicing fidelity.

39 citations

humanexperimental assay

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Molecular BiologyeLifePeer-reviewedMay 16, 2022

Dynamics of transcription elongation are finely tuned by dozens of regulatory factors

Mary Couvillion, Kevin M. Harlen, Kate C Lachance…·L. Stirling Churchman

The paper quantifies how transcription elongation in yeast is regulated by multiple factors balancing Pol II activity and gene expression.

22 citations

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