Mary Couvillion

The paper shows that FASTKD4-dependent processing of mitochondrial RNA junctions is required for efficient CYB translation by removing RNA structures that hinder mitoribosome engagement.

The paper introduces AIR-seq, a method that measures RNA dynamics without chemical conversion, improving RNA velocity inference and revealing hidden regulation.

The paper investigates how mitochondrial translational activators (TAs) facilitate transcript-specific translation initiation by aligning mRNAs at the small mitoribosomal subunit.

The paper identifies a molecular switch at the yeast mitoribosomal tunnel exit that regulates cytochrome b synthesis by mediating interactions between translational activators and assembly factors.

This study investigates how chloramphenicol and oxazolidinone antibiotics inhibit mitochondrial ribosomes, finding context-specific stalling similar to their bacterial action.

The paper uses long-read single-molecule accessibility mapping to reveal that human mtDNA undergoes all-or-none global compaction, with most nucleoids in an inaccessible state.

The paper quantifies how transcription elongation in yeast is regulated by multiple factors balancing Pol II activity and gene expression.