Hypomorphic NOTCH1 Expression Alters Cardiomyocyte Cellular Architecture in Hypoplastic Left Heart Syndrome
Jordann Lewis, Travis B. Lear, Brent Schlegel, Dominic Woods, Krithika Rao, Amy Isabella Sentis, Jay Xiaojun Tan, Rajaganapathi Jagannathan, Zaineb Javed, Aine N. Boudreau, Timothy J. Nelson, Mousumi Moulik, Nadine Hempel, Bill B. Chen, Sruti Shiva, , Anita P. Saraf
This paper uses CRISPR-edited human iPSCs with hypomorphic NOTCH1 to model hypoplastic left heart syndrome, identifying auranofin as a potential therapeutic.
bioRxiv · Sep 30, 2024 · PreprintCell Biology