Jay Xiaojun Tan

This study identifies SOLAR as a lysosomal quality control pathway that links CASM to p62-driven membrane repair and redox signaling, with implications for aging and degenerative disease.

This study identifies phosphoinositides and cholesterol as regulators of STING activation by promoting its oligomerization and translocation.

This study identifies PtdIns(3,5)P2 as an endogenous ligand of STING that cooperates with cGAMP to activate innate immune signaling.

This paper uses CRISPR-edited human iPSCs with hypomorphic NOTCH1 to model hypoplastic left heart syndrome, identifying auranofin as a potential therapeutic.