Sruti Shiva

The paper examines the mRNA abundance of RIDD target genes in heart failure patients and mice, finding decreased expression consistent with RIDD activation.

This study shows nitrite reduces vascular smooth muscle cell proliferation and intimal hyperplasia by increasing mitofusin-1 levels and mitochondrial fusion.

This study shows that germline loss reduces mitochondrial volume and respiratory function in young adulthood but preserves mitochondrial activity during aging and hypothermia, mediated by NHR-49/PPAR.

This paper uses CRISPR-edited human iPSCs with hypomorphic NOTCH1 to model hypoplastic left heart syndrome, identifying auranofin as a potential therapeutic.

The paper identifies mtDNA damage as a blood-based biomarker for Parkinson's disease, showing increased levels in early-stage patients and mutation carriers, suggesting its potential for patient stratification in clinical trials.

This study shows that myocardial BDNF signaling via YY1 regulates cardiac bioenergetics and mitochondrial function during stress.

This study shows that Cdk2 is required for platelet activation by inhibiting PP1 phosphatase activity and promoting Erk activation through phosphorylation of PPP1R12a.