Yizhou Dong

The paper identifies a set of 10 ISGs that confer broad-spectrum antiviral resistance and demonstrates their efficacy in protecting against multiple viruses in vivo.

This study shows that deleting ZNRF3 and RNF43 in hepatocytes after MASH onset restores liver regeneration and reverses steatosis, inflammation, and fibrosis without causing tumorigenesis or hepatotoxicity.

This paper designs a drug-regulated gene expression system using self-amplifying RNA with TMP-responsive degradation domains, showing enhanced immune responses in mice.

This study shows that co-delivering siRNA targeting IFNAR1 with RNA vaccines enhances antigen expression, immune cell infiltration, and antibody and T cell responses.

This paper develops a method to conjugate bispecific antibodies to lipid nanoparticles for targeted mRNA delivery, showing improved efficiency and specificity in transfecting specific cell types.