ImmunologybioRxiv
Visualizing and manipulating hyperstabilization of T cell microvilli contacts by engineered chimeric antigen receptors
C. Beppler, J. Eichorst, K. Marchuk…·M. F. Krummel
This study uses advanced imaging to show that engineered CARs with high affinity hyperstabilize T cell microvilli contacts, impairing function, while reducing affinity restores normal dynamics and improves effector function.