K. Marchuk

T cells use distinct topological and membrane receptor scanning strategies that individually coalesce during receptor recognition

This study shows T cells use independent scanning strategies for microvilli and receptor patches, which coalesce during receptor recognition.

Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

This study investigates the interaction between macrophages and exhausted CD8+ T cells in the tumor microenvironment, showing they form a feedback loop that promotes tumor survival.

Visualizing and manipulating hyperstabilization of T cell microvilli contacts by engineered chimeric antigen receptors

This study uses advanced imaging to show that engineered CARs with high affinity hyperstabilize T cell microvilli contacts, impairing function, while reducing affinity restores normal dynamics and improves effector function.

WAVE complex self-organization templates lamellipodial formation

The paper investigates how the WAVE complex self-organizes into linear structures to form lamellipodia, contrasting with N-WASP's spiky actin networks, and shows how curvature sensing enables cell shape regulation.

Tumors Exploit Dedicated Intracellular Vesicles to Program T cell Responses

The paper shows myeloid cells transfer tumor antigen-laden vesicles to APCs, directing T cell responses away from memory phenotypes.