Author

C. A. Francis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Biophysics· 1 Ecology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Research Focus:ecology & biodiversity· 1 Approach:genetic perturbation / CRISPR· 1 Assay:metagenomics· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

H. Demirci· 3 shared S. Wakatsuki· 3 shared Y. Yoshikuni· 3 shared B. B. Tolar· 2 shared A. Gomez· 1 shared A. M. Florence· 1 shared A. N. Rasmussen· 1 shared A. Pal· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiophysics

H. Demirci

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Crystal Structure of the 4-Hydroxybutyryl-CoA Synthetase (ADP-forming) from Nitrosopumilus maritimus

J. A. Johnson, B. B. Tolar, B. Tosun, Y. Yoshikuni, C. A. Francis, S. Wakatsuki, H. Demirci

The paper presents the crystal structure of Nmar_0206 from Nitrosopumilus maritimus, revealing a conserved interdomain linker loop that influences homodimer stability and contributes to the enzyme's energy efficiency in the 3HP/4HB cycle.

bioRxiv · Jul 14, 2023Biophysics

Ecophysiology and genomics of the brackish water adapted SAR11 subclade IIIa

V. C. Lanclos, A. N. Rasmussen, C. Y. Kojima, C. Cheng, M. W. Henson, B. C. Faircloth, C. A. Francis, C. Thrash

This study presents the most comprehensive pangenomic analysis of SAR11 subclade IIIa, revealing ecological and metabolic differentiation across its subgroups and bridging marine and freshwater adaptations.

bioRxiv · Aug 2, 2022Microbiology

Structural Insights into Bifunctional Thaumarchaeal Crotonyl-CoA Hydratase and 3-Hydroxypropionyl-CoA Dehydratase from Nitrosopumilus maritimus

E. Destan, B. Yuksel, B. B. Tolar, E. Ayan, S. Deutsch, Y. Yoshikuni, S. Wakatsuki, C. A. Francis, H. DeMirci

This study presents the first high-resolution crystal structure of a bifunctional enzyme involved in the 3HP/4HB cycle in Nitrosopumilus maritimus, revealing its dual catalytic activities.

bioRxiv · Sep 22, 2021 · PreprintBiochemistry

Structural adaptation of oxygen tolerance in 4-hydroxybutyrl-CoA dehydratase, a key enzyme of archaeal carbon fixation

H. DeMirci, B. Tolar, T. Doukov, A. Petriceks, A. Pal, Y. Yoshikuni, A. Gomez, D. A. Saez, E. Vohringer-Martinez, T. Schwander, T. J. Erb, C. A. Francis, S. Wakatsuki

The paper investigates how 4HBD, a key enzyme in archaeal carbon fixation, adapted structurally to become oxygen-tolerant, revealing evolutionary changes that enabled aerobic metabolism.

bioRxiv · Feb 5, 2020 · PreprintEvolutionary Biology

Aerobic heterotrophy and RuBisCO-mediated CO2 metabolism in marine Thaumarchaeota

L. Reji, C. A. Francis

This study identifies a marine Thaumarchaeota clade that uses aerobic heterotrophy and RuBisCO-mediated carbon metabolism, revealing an evolutionary link between anaerobic and aerobic lineages.

bioRxiv · Dec 22, 2019Microbiology

Cover crop mixture diversity, biomass productivity, weed suppression, and stability

A. M. Florence, L. G. Higley, R. A. Drijber, C. A. Francis, J. L. Lindquist

This study tests diversity-productivity, diversity-invasibility, and diversity-stability hypotheses in cover crop mixtures, finding that diversity does not consistently increase biomass, weed suppression, or stability.

bioRxiv · Oct 10, 2018Ecology