H. DeMirci

4D Crystallography Captures Transient IF1-Ribosome Dynamics in Translation Initiation

This study uses 4D crystallography to capture transient dynamics of IF1 binding to the 30S ribosomal subunit, revealing allostery and interactions during translation initiation.

Ambient Temperature Bacterial Large Ribosomal Subunit Structure Enabled by Serial Femtosecond X-ray Crystallography

This study determines the structure of the 50S ribosomal subunit from Thermus thermophilus at ambient temperature using serial femtosecond X-ray crystallography, revealing new dynamics and antibiotic binding sites.

Crystal Structure of the 4-Hydroxybutyryl-CoA Synthetase (ADP-forming) from Nitrosopumilus maritimus

The paper presents the crystal structure of Nmar_0206 from Nitrosopumilus maritimus, revealing a conserved interdomain linker loop that influences homodimer stability and contributes to the enzyme's energy efficiency in the 3HP/4HB cycle.

Comparative Study of High-resolution LysB29(Nε-myristoyl) des(B30) Insulin Structures Display Novel Dynamic Causal Interrelations in Monomeric-Dimeric Motions

The paper compares high-resolution crystal structures of insulin detemir to identify dynamic conformational changes and their implications for oligomeric equilibrium.

Immunosuppression with Cyclosporine versus Tacrolimus shows distinctive nephrotoxicity profiles within renal compartments

This study compares nephrotoxicity of cyclosporine and tacrolimus in rat kidneys using multiomics and histopathology, revealing distinct damage patterns in glomerular and tubular compartments.

Ambient temperature crystal structure of Escherichia coli CyaY protein displays alternate conformation

The paper presents the first ambient temperature crystal structure of Escherichia coli CyaY, revealing an alternate conformation and highlighting temperature's impact on protein structure.

Structural Analysis of Wild-type and Val120Thr Mutant Candida boidinii Formate Dehydrogenase by X-ray Crystallography

This study reports X-ray crystal structures of wild-type and Val120Thr mutant CbFDH, revealing structural changes that may enhance enzyme stability and electron transfer efficiency.

Rapid and Efficient Ambient Temperature X-ray Crystal Structure Determination at Turkish Light Source

The paper introduces a plate-reader module for rapid ambient temperature X-ray crystallography at a home source and reports the first lysozyme structure determined at Turkish DeLight.

Inter-subunit coupling enables fast CO2-fixation by reductive carboxylases

This paper investigates the structural and dynamic mechanisms of CO2 fixation by ECRs, revealing inter-subunit coupling that enables fast catalytic activity.

Cooperative Allostery and Structural Dynamics of Streptavidin at Cryogenic- and Ambient-temperature

The paper presents two apo-streptavidin structures at different temperatures and reveals cooperative allostery through water-mediated interactions.

Structural Insights into Bifunctional Thaumarchaeal Crotonyl-CoA Hydratase and 3-Hydroxypropionyl-CoA Dehydratase from Nitrosopumilus maritimus

This study presents the first high-resolution crystal structure of a bifunctional enzyme involved in the 3HP/4HB cycle in Nitrosopumilus maritimus, revealing its dual catalytic activities.

Structural insight into host plasma membrane association and assembly of HIV-1 Matrix protein

This study presents crystal structures of HIV-1 MA domain bound to IP6, revealing its binding mode and interaction with PIP2, providing insights into virion assembly.

The neutralization effect of Montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies

This paper shows Montelukast inhibits SARS-CoV-2 by targeting both Spike/ACE2 and main protease through in silico and in vitro studies.

Structural adaptation of oxygen tolerance in 4-hydroxybutyrl-CoA dehydratase, a key enzyme of archaeal carbon fixation

The paper investigates how 4HBD, a key enzyme in archaeal carbon fixation, adapted structurally to become oxygen-tolerant, revealing evolutionary changes that enabled aerobic metabolism.

Serial femtosecond X-ray diffraction of HIV-1 Gag MA-IP6 microcrystals at ambient temperature

This study uses serial femtosecond X-ray crystallography to analyze HIV-1 Gag MA-IP6 microcrystals at ambient temperature, achieving high-resolution diffraction data.

Aminoglycoside ribosome interactions reveal novel conformational states at ambient temperature

This study examines aminoglycoside interactions with the bacterial 30S ribosome at ambient and cryogenic temperatures, revealing temperature-sensitive conformational changes and new structural states.

Structure of the 30S ribosomal decoding complex at ambient temperature

The paper reports an ambient-temperature X-ray crystal structure of the Thermus thermophilus 30S ribosomal decoding complex, showing consistency with cryogenic structures but with minor conformational variations.