Author

C. A. G. Booth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

A. A. Lane· 1 shared A. Hamblin· 1 shared A. Mead· 1 shared A. Rao· 1 shared A. Rodriguez Meira· 1 shared A. Roy· 1 shared B. Povinelli· 1 shared D. Iskander· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. A. Lane

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2 papers

Recent·Most cited

Targetable leukemia dependency on noncanonical PI3Kγ signaling

Q. Luo, E. G. Raulston, M. A. Prado, X. Wu, K. Gritsman, C. A. G. Booth, R. Xu, P. van Galen, J. G. Doench, S. Shimony, H. W. Long, D. S. Neuberg, J. A. Paulo, A. A. Lane

This study identifies a targetable dependency on noncanonical PI3Kγ signaling in acute leukemias, showing that PI3Kγ inhibition with eganelisib improves survival when combined with cytarabine.

bioRxiv · Dec 15, 2023 · PreprintCancer Biology

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia

E. Louka, B. Povinelli, A. Rodriguez Meira, G. Buck, N. Ashley, A. Hamblin, C. A. G. Booth, N. Sousos, A. Roy, N. Elliott, D. Iskander, J. De la Fuente, N. Fordham, S. O'Byrne, S. Inglott, , A. Mead

This study identifies heterogeneous leukemia stem cells in JMML using single-cell RNA-sequencing and clonogenic assays, revealing their molecular features and potential therapeutic targets.

bioRxiv · May 7, 2019Cancer Biology