Author

M. A. Prado

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:differential expression· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. Finley· 4 shared J. A. Paulo· 4 shared S. P. Gygi· 3 shared J. Frydman· 2 shared A. A. Lane· 1 shared A. Easton· 1 shared A. M. Whiteley· 1 shared A. Stolz· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersCell Biology

D. Finley

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Targetable leukemia dependency on noncanonical PI3Kγ signaling

Q. Luo, E. G. Raulston, M. A. Prado, X. Wu, K. Gritsman, C. A. G. Booth, R. Xu, P. van Galen, J. G. Doench, S. Shimony, H. W. Long, D. S. Neuberg, J. A. Paulo, A. A. Lane

This study identifies a targetable dependency on noncanonical PI3Kγ signaling in acute leukemias, showing that PI3Kγ inhibition with eganelisib improves survival when combined with cytarabine.

bioRxiv · Dec 15, 2023 · PreprintCancer Biology

Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease

C.-C. Chou, R. Vest, M. A. Prado, J. Wilson-Grady, J. A. Paulo, Y. Shibuya, P. Moran-Losada, T.-T. Lee, J. Luo, S. P. Gygi, J. W. Kelly, D. Finley, M. Wernig, T. Wyss-Coray, J. Frydman

This study uses transdifferentiated neurons to show lysosomal deficits are an early event in aging and Alzheimer's disease, leading to proteotoxic deposits and cell death.

bioRxiv · Mar 27, 2023Cell Biology

An mTOR-independent Macroautophagy Activator Ameliorates Tauopathy and Prionopathy Neurodegeneration Phenotypes

L. Yoon, R. C. Botham, A. Verhelle, Y. Wu, C. Cole, E. P. Tan, L. A. Massey, P. Sanz-Martinez, C. C. Chou, J. Xu, L. P. Elia, K. Lee, S. R. Labra, G. M. Kline, Q. Xiao, , S. Encalada

The paper identifies CCT020312, an mTOR-independent autophagy activator, which reduces tauopathy and prionopathy neurodegeneration phenotypes by enhancing autophagy flux and clearing protein aggregates.

bioRxiv · Sep 29, 2022 · PreprintCell Biology

Global proteome metastability response in isogenic animals to missense mutations and polyglutamine expansions in aging

X. Sui, M. A. Prado, J. A. Paulo, S. P. Gygi, D. Finley, R. I. Morimoto

This study examines how proteome conformational stability changes in aging C. elegans due to missense mutations and polyglutamine expansions, revealing age-dependent metastable protein networks.

bioRxiv · Sep 28, 2022 · PreprintBiochemistry

Global proteomics of Ubqln2-based murine models of ALS

A. M. Whiteley, M. A. Prado, S. A. H. de Poot, J. A. Paulo, M. Ashton, S. Dominguez, M. Weber, H. Ngu, J. Szpyt, M. P. Jedrychowski, A. Easton, S. P. Gygi, T. Kurz, M. J. Monteiro, E. J. Brown, D. Finley

The paper identifies proteomic changes in Ubqln2 mutant mice and finds that TRIM32, PEG10, and CXX1B are linked to UBQLN2 function and degradation.

bioRxiv · Feb 22, 2020Cell Biology