Author

K. Gritsman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

S. Takeishi· 2 shared T. Marchand· 2 shared A. A. Lane· 1 shared A. Bergman· 1 shared A. Birbrair· 1 shared A. Verma· 1 shared C. A. G. Booth· 1 shared C. Guha· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

S. Takeishi

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Targetable leukemia dependency on noncanonical PI3Kγ signaling

Q. Luo, E. G. Raulston, M. A. Prado, X. Wu, K. Gritsman, C. A. G. Booth, R. Xu, P. van Galen, J. G. Doench, S. Shimony, H. W. Long, D. S. Neuberg, J. A. Paulo, A. A. Lane

This study identifies a targetable dependency on noncanonical PI3Kγ signaling in acute leukemias, showing that PI3Kγ inhibition with eganelisib improves survival when combined with cytarabine.

bioRxiv · Dec 15, 2023 · PreprintCancer Biology

Haematopoietic stem cell numbers are not solely determined by niche availability

S. Takeishi, T. Marchand, W. R. Koba, D. K. Borger, C. Xu, C. Guha, A. Bergman, P. S. Frenette, K. Gritsman, U. Steidl

This study challenges the idea that HSC numbers are solely determined by niche availability, showing systemic and local constraints on HSC numbers regardless of niche changes.

bioRxiv · Oct 28, 2023 · PreprintCell Biology

Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury

T. Marchand, K. E. Akinnola, S. Takeishi, M. Maryanovich, S. Pinho, J. Saint-Vanne, A. Birbrair, T. Lamy, K. Tarte, P. Frenette, K. Gritsman

bioRxiv · Jan 12, 2023Cell Biology

Deletion of PI3-Kinase Promotes Myelodysplasia Through Dysregulation of Autophagy in Hematopoietic Stem Cells

K. Ames, I. Kaur, Y. Shi, M. M. Tong, T. Sinclair, S. Hemmati, S. G. Glushakow-Smith, E. E. Tein, L. Gurska, R. Dubin, J. Shan, K. Pradhan, A. Verma, C. Montagna, K. Gritsman

This study shows that deleting all three Class IA PI3K isoforms in HSCs leads to myelodysplasia through impaired autophagy, which affects differentiation and multilineage repopulation.

bioRxiv · Dec 4, 2020 · PreprintCancer Biology