Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
16 papers
Recent·Most cited
N. Joharinia, E. Bonneil, N. Grandvaux, P. Thibault, R. Lippe
This study identifies host proteins incorporated into HCoV-OC43 virions and virus-modulated extracellular vesicles, revealing their roles in viral spread and extracellular vesicle composition.
bioRxiv · May 16, 2024Microbiology
A. Kazanova, J. Sung, N. L. Oliveira, C. Gavino, H. Bessaiah, J. Pei, L. Burns, W. Miller, M. Brouillard-Galipeau, L. Zhu, L. M. Guerra, M. N. Elemeery, S. J. Recinto, A. MacDonald, J. Lanoix, , S. Gruenheid
This study shows that Helicobacter pylori infection in Pink1-/- mice causes motor and cognitive dysfunction linked to CD8 T cell activity, mimicking early PD features.
bioRxiv · Feb 25, 2024 · PreprintImmunology
J.-D. Larouche, C. M. Laumont, A. Trofimov, K. Vincent, L. Hesnard, S. Brochu, C. Cote, J. Humeau, E. Bonneil, J. Lanoix, C. Durette, P. Gendron, J.-P. Laverdure, E. R. Richie, S. Lemieux, , C. Perreault
This study investigates the role of transposable elements in thymus development and function, showing their interactions with transcription factors and their impact on T-cell tolerance.
bioRxiv · Jul 12, 2023Immunology
A. M. Fahmy, T. Cannon, C. H. Paredes, A. Ahmadi, Y. Z. Xu, B. Barette, M. Ibrahim, J. Lanoix, G. Arango-Duque, E. Schurr, E. Chevet, P. Thibault, S. Gruenheid, H. McBride, M. Desjardins
This study identifies LRRK2 as a regulator of the unfolded protein response and antigen presentation in macrophages during inflammation, linking it to immune response mechanisms.
bioRxiv · Jun 14, 2023 · PreprintImmunology
H. Garadi Suresh, E. Bonneil, B. Albert, C. Dominique, M. Costanzo, C. Pons, M. P. D. Masinas, E. Shuteriqi, D. Shore, A. K. Henras, P. Thibault, C. Boone, B. J. Andrews
bioRxiv · May 3, 2023 · PreprintCell Biology
N. Noronha, C. Durette, B. E Silva, J. Courtois, J. Humeau, A. Sauvat, M.-P. Hardy, K. Vincent, J.-P. Laverdure, J. Lanoix, F. Baron, P. Thibault, C. Perreault, G. Ehx
This study shows that 5-azacytidine induces endogenous retroelement transcripts in AML cells, which are degraded by autophagy and not presented as MHC-I peptides, and that autophagy inhibition enhances immune responses.
bioRxiv · Dec 2, 2022Immunology
M. V. Ruiz Cuevas, M.-P. Hardy, J.-D. Larouche, A. Apavaloaei, E. Kina, K. Vincent, P. Gendron, J.-P. Laverdure, C. Durette, P. Thibault, S. Lemieux, C. Perreault, G. Ehx
BamQuery quantifies MAPs from various genomic regions in bulk and single-cell RNA-seq data, revealing non-canonical sources of tumor antigens and viral peptides.
bioRxiv · Oct 7, 2022Immunology
J. A. Acklin, A. R. Patel, A. P. Kurland, S. Horiuchi, A. S. Moss, E. J. Degrace, S. Ikegame, J. Carmichael, S. Kowdle, P. Thibault, N. Imai, H. Ueno, B. Tweel, J. R. Johnson, B. R. Rosenberg, , J. K. Lim
The paper infects human lymphoid explants with measles virus and uses scRNA-Seq and flow cytometry to identify B cell preference and T cell resistance, along with ISG protein induction.
bioRxiv · Sep 12, 2022Immunology
S. L. L. Park, U. N. Ramirez Jarquin, N. Shahani, O. Rivera, M. Sharma, F. P. McManus, P. Thibault, S. Subramaniam
This study identifies SUMO modification of GβL as a regulator of mTOR complex assembly and activity, showing that SUMOylation is essential for proper mTOR signaling.
bioRxiv · Sep 3, 2020Biochemistry
D. E. MacNeil, P. Lambert-Lanteigne, J. Qin, F. McManus, E. Bonneil, P. Thibault, C. Autexier
This study identifies SUMOylation sites in dyskerin that regulate its nuclear and subnuclear localization, essential for its function in telomerase and H/ACA ribonucleoprotein complexes.
bioRxiv · Sep 2, 2020Cell Biology
S. Subramaniam, O. Rivera, M. Sharma, N. Shahani, G. Crynen, P. Karunadharma, F. McManus, P. Thibault
This study identifies Rhes as a regulator of SUMOylation of nuclear proteins and shows its role in modulating striatal gene expression through SUMO-dependent mechanisms.
bioRxiv · Jun 18, 2020Biochemistry
D. Garrido, M. Bourouh, E. Bonneil, P. Thibault, A. Swan, V. Archambault
This study identifies Cyclin B3 as a kinase that activates the APC/C by phosphorylating its subunits, facilitating chromosome segregation in both meiosis and mitosis.
bioRxiv · Jun 5, 2020Cell Biology
S. Tollis, J. Singh, Y. Thattikota, R. Palou, G. Ghazal, J. Coulombe-Huntington, X. Tang, S. Moore, D. Blake, E. Bonneil, C. A. Royer, P. Thibault, M. Tyers
The paper identifies NRS1, a nitrogen-responsive microprotein in budding yeast, that provides an alternative mechanism for G1/S transcriptional activation under poor nitrogen conditions.
bioRxiv · Apr 20, 2020 · PreprintCell Biology
D. Blanco-Melo, B. E. Nilsson-Payant, S. Uhl, B. Escudero, S. Olschewski, P. Thibault, M. Panis, M. Rosenthal, C. Munoz-Fontela, B. Lee, B. tenOever
The paper shows that limiting nucleoprotein (NP) in negative-sense RNA viruses leads to defective genomes and triggers host interferon responses, making NP a key antiviral target.
bioRxiv · Mar 12, 2020 · PreprintMicrobiology
C. Li, F. P. McManus, C. Plutoni, C. M. Pascariu, T. Nelson, L. E. Alberici Delsin, G. Emery, P. Thibault
The paper identifies novel PIAS1 substrates using quantitative proteomics, revealing a role for PIAS1 in cell migration via SUMOylation of Vimentin.
bioRxiv · Apr 23, 2019Cancer Biology
I. Baccelli, Y. Gareau, B. Lehnertz, S. Gingras, J.-F. Spinella, A. Beautrait, S. Corneau, N. Mayotte, I. Boivin, S. Girard, T. MacRae, M. Frechette, K. Leveille, J. Krosl, C. Thiollier, , G. Sauvageau
The paper identifies Mubritinib as an ETC1 inhibitor effective against chemotherapy-resistant AML subtypes with OXPHOS hyperactivity and specific mutations.
bioRxiv · Jan 15, 2019 · PreprintCancer Biology