Statins and genetic inhibition of the mevalonate pathway activate an ATF3-STMN2 regenerative program
Matthew Nolan, Sandeep Aryal, I. Sandra Ndayambaje, Maize Cao, Peyton Lee, Moriah J. Hovde, Shuqi Yun, Josette J Wlaschin, Aaron Held, Hortense D. A. M. Beaussant, Benjamin Wymann, Chao-Zong Lee, Su Min Lim, Xin Jiang, Nandini Ramesh, , Clotilde Lagier‐Tourenne
The paper shows statins and mevalonate pathway inhibition increase STMN2 and ATF3, promoting neuronal regeneration in neurodegenerative disease.
bioRxiv · Feb 24, 2026 · PreprintNeuroscience