Author

C. B. Carbone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:spatial transcriptomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

R. Vale· 2 shared A. N. Parikh· 1 shared A. Ritter· 1 shared A. Yang· 1 shared C. Eduardo de Andrea· 1 shared C. Gomez-Roca· 1 shared C. Moussion· 1 shared D. Orlova· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiophysics

R. Vale

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Author profile →

3 papers

Recent·Most cited

Surveillance of in situ tumor arrays reveals early environmental control of cancer immunity

G. Ortiz-Munoz, M. Brown, C. B. Carbone, J. Pechuan Jorge, A. Ritter, D. Orlova, S. R. Mantri, A. Yang, J. Doerr, S. Mariathasan, Y. Wang, S. Turley, C. Gomez-Roca, C. Eduardo de Andrea, D. Spigel, , C. Moussion

This study introduces STAMP, a method to monitor tumor-immune dynamics in vivo, showing immune phenotypes evolve over time and correlate with therapeutic response.

bioRxiv · May 27, 2021 · PreprintCancer Biology

Coupling between lipid miscibility and phosphotyrosine driven protein condensation at the membrane

J. K. Chung, W. Y. C. Huang, C. B. Carbone, L. M. Nocka, A. N. Parikh, R. Vale, J. T. Groves

The paper shows that LAT protein condensation on membrane surfaces drives lipid phase separation, which in turn localizes K-Ras into the condensate, controlled by tyrosine phosphorylation.

bioRxiv · Jul 22, 2020 · PreprintBiophysics

In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase

C. B. Carbone, N. Kern, R. A. Fernandes, E. Hui, X. Su, K. C. Garcia, R. Vale

This paper demonstrates that TCR-pMHC and PD-1-PD-L1 interactions can exclude CD45 from membrane interfaces, creating spatial organization that may regulate T cell signaling.

bioRxiv · Jun 7, 2017Immunology