Author

M. D. Young

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 6 Organism:human· 6 Approach:statistical model· 6 Research Focus:cell type annotation· 5 Assay:scRNA-seq· 4 Assay:bulk RNA-seq· 3 Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

S. Behjati· 5 shared L. Mamanova· 4 shared M. Haniffa· 4 shared A. Piapi· 3 shared C. Thevanesan· 3 shared E. Prigmore· 3 shared G. Kildisiute· 3 shared K. Roberts· 3 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCancer Biology

S. Behjati

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Author profile →

6 papers

Recent·Most cited

Single cell transcriptomics reveals chondrocyte differentiation dynamics in vivo and in vitro

J. E. G. Lawrence, S. Woods, K. Roberts, D. N. Sumanaweera, P. Balogh, A. V. Predeus, P. He, T. Li, K. Polanski, E. Prigmore, E. Tuck, L. Mamanova, D. Zhou, S. Webb, L. Jardine, , S. Teichmann

This study uses single-cell transcriptomics to compare in vitro and in vivo chondrocyte differentiation, identifies off-target differentiation, and improves in vitro protocols by inhibiting FOXO1.

bioRxiv · Dec 20, 2023Bioengineering

Transcriptional signals of dedifferentiation in human cancer

G. Kildisiute, M. Kalyva, R. Elmentaite, S. van Dongen, C. Thevanesan, A. Piapi, K. Ambridge, E. Prigmore, M. Haniffa, S. A. Teichmann, K. Straathof, I. Cortes-Ciriano, S. Behjati, M. D. Young

This study examines dedifferentiation in cancer using single-cell atlases, finding that adult cancers do not revert to an embryonic state but retain foetal signals, while childhood cancers show universal foetal state features.

bioRxiv · Nov 28, 2022 · PreprintCancer Biology

Clonal diversification and histogenesis of malignant germ cell tumours

T. R. W. Oliver, L. Chappell, R. Sanghvi, L. Deighton, N. Ansari-Pour, S. Dentro, M. D. Young, T. H. H. Coorens, H. Jung, T. M. Butler, M. D. C. Neville, D. Leongamornlert, M. A. Sanders, Y. Hooks, A. Cagan, , S. Behjati

This study analyzes the genome and transcriptome of 547 GCT histological units to explore clonal diversification and histogenesis, finding unifying genomic and transcriptional features across GCTs.

bioRxiv · Feb 1, 2022Cancer Biology

Tumor to normal single cell mRNA comparisons reveal a pan-neuroblastoma cancer cell

G. Kildisiute, W. M. Kholosy, M. D. Young, K. Roberts, R. Elmentaite, S. R. van Hooff, E. Khabirova, A. Piapi, C. Thevanesan, E. Bugallo Blanco, C. Burke, L. Mamanova, P. Lijnzaad, T. Margaritis, F. C. P. Holstege, , S. Behjati

The paper compares tumor and normal single-cell mRNA data to show neuroblastoma cells resemble fetal sympathoblasts across diverse samples.

bioRxiv · Jun 22, 2020Cancer Biology

Cellular mRNA signals in human kidney tumors

M. D. Young, T. J. Mitchell, L. M. Custers, T. Margaritis, F. Morales, K. Kwakwa, E. Khabirova, G. Kildisiute, T. R. Oliver, R. R. d. Krijger, M. M. v. d. Heuvel-Eibrink, F. Comitani, A. Piapi, E. B. Blanco, C. Thevanesan, , Holste

This study analyzes mRNA signals in 1,300 kidney tumors to determine their differentiation state and origin, finding that childhood tumors show fetal signals while most adult tumors do not, with exceptions in certain cancer types.

bioRxiv · Mar 19, 2020Cancer Biology

Single-cell sequencing reveals a clonal expansion of pro-inflammatory synovial CD8 T cells expressing tissue homing receptors in psoriatic arthritis

F. Penkava, M. Del Castillo Velasco-Herrera, M. D. Young, N. Yager, A. Lledo Lara, C. Guzzo, A. Maroof, L. Mamanova, S. Cole, M. Efremova, D. Simone, C. C. Brown, A. L. Croxford, S. Teichmann, P. Bowness, , M. H. Al-Mossawi

The paper identifies clonal expansion of pro-inflammatory CD8 T cells in psoriatic arthritis joints using single-cell sequencing and links them to tissue homing receptors and antigen specificity.

bioRxiv · Jul 16, 2019Immunology