C. C. Hedrick

Modeling the evolutionary history of nonclassical monocytes in mammals

This study models the evolutionary history of nonclassical monocytes, finding their production is unique to mammals.

Sex differences in coronary artery disease and diabetes revealed by scRNA-Seq and CITE-Seq of human CD4+ T cells

The paper uses scRNA-Seq and CITE-Seq to analyze CD4+ T cells from patients with and without coronary artery disease and diabetes, identifying sex-specific differences and gene expression patterns.

Combined protein and transcript single cell RNA sequencing in human peripheral blood mononuclear cells

The paper develops combined protein and transcript single-cell RNA sequencing in PBMCs, identifying more cell subsets than traditional methods and showing disease-related transcriptome differences in HIV patients.

Interplay of Monocytes and T Lymphocytes in COVID-19 Severity

The study uses mass cytometry to analyze immune cell subsets in convalescent COVID-19 patients, linking monocyte and T cell populations to disease severity and clinical markers.

Lack of apolipoprotein A1 impairs optimal regulatory T cell homeostasis at steady state due to impaired IL-2 signaling

This study shows that ApoA1 deficiency impairs Treg cell homeostasis and function through reduced IL-2 signaling and altered cholesterol content in mice.

Bone marrow transplantation rescues monocyte recruitment defect and improves cystic fibrosis in mice

This study shows bone marrow transplantation improves survival and reduces inflammation in CFTRΔF508 mice by rescuing monocyte adhesion defects.