P. Vijayanand

Distinct super-enhancer elements differentially control Il2ra gene expression in a cell-type specific fashion

The paper identifies distinct super-enhancer elements that differentially regulate Il2ra expression in DN2/DN3 thymocytes and Treg cells versus mature T and NK cells.

Transcriptomes and metabolism define mouse and human MAIT cell heterogeneity

This study identifies MAIT cell heterogeneity in mice and humans through single-cell RNA sequencing and metabolic analysis, revealing distinct transcriptomes and metabolic states in different tissues and species.

CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature

This study identifies CD4+CCR6+ T cells as key drivers of the BCG-induced transcriptional response, showing similar immune signatures across individuals.

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response

The paper identifies germline variants associated with the tumor immune microenvironment, linking them to cancer risk and immunotherapy response.

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.

The paper identifies COVID-19 risk variants associated with gene expression in multiple immune cell types, revealing potential mechanisms linking genetic risk to disease severity.

Transcriptome and Chromatin Landscape of iNKT cells are Shaped by Subset Differentiation and Antigen Exposure

This study examines how iNKT cell subsets change in gene programs and chromatin structure across tissues and after antigen exposure, revealing long-term adaptability.

Interplay of Monocytes and T Lymphocytes in COVID-19 Severity

The study uses mass cytometry to analyze immune cell subsets in convalescent COVID-19 patients, linking monocyte and T cell populations to disease severity and clinical markers.

Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4+ T cells

This study analyzes single-cell transcriptomes of SARS-CoV-2 reactive CD4+ T cells in COVID-19 patients, finding differences in cell types and gene expression between severe and mild disease.

The challenge of distinguishing cell-cell complexes from singlet cells in non-imaging flow cytometry and single-cell sorting

The paper identifies molecular signatures and methods to distinguish cell-cell complexes from singlet cells in flow cytometry data, highlighting their impact on data interpretation.

CD4+ follicular helper-like T cells are key players in anti-tumor immunity

The paper identifies CD4+ follicular helper-like T cells as critical for enhancing anti-tumor CD8+ T cell responses and tumor growth inhibition.

CyTOF reveals phenotypically-distinct human blood neutrophil populations differentially correlated with melanoma stage

This study uses CyTOF to identify 7 neutrophil clusters in melanoma patients, finding correlations with disease stage and diverse functional capacities.

No cell is an island: circulating T cell:monocyte complexes are markers of immune perturbations

The paper identifies T cell:monocyte complexes in human blood as biological immune interactions, not technical artifacts, and shows their frequency changes with immune perturbations.

Evidence that recurrent Group A streptococcus tonsillitis is animmunosusceptibility disease involving antibody deficiency and aberrant Tfh cells

The paper investigates recurrent Group A Streptococcus tonsillitis and finds it involves antibody deficiency and aberrant Tfh cells, with genetic factors contributing to susceptibility.