P. Griffin

Development of antibacterial drug plus bacteriophage combination assays

This study evaluates how phages interact with antibacterials using standardized assays and finds that phages can increase or decrease antibiotic MICs depending on the strain and combination.

RIG-I uses its intrinsically disordered CARDs-Helicase linker in RNA proofreading functions

This study identifies a proofreading mechanism in RIG-I that uses the CARDs-Helicase Linker to gate RNA specificity and stabilize interactions, preventing non-specific RNA engagement.

Ultrastructural insight into SARS-CoV-2 attachment, entry and budding in human airway epithelium

This study uses electron microscopy to examine SARS-CoV-2 infection in human airway epithelium, showing viral entry through the plasma membrane and budding from intracellular compartments.

Structural insights into the role of Dicer-related helicase 3 in RNAi in Caenorhabditis elegans.

This study determines the crystal structures of DRH-3 domains bound to RNA, revealing structural features that explain its role in RNAi and evolutionary divergence from Dicer-like helicases.

PPARG in osteocytes is essential for sclerostin expression, bone mass, marrow adiposity and TZD-induced bone loss

Discovery of a Novel, Selective and Short-Acting Skeletal Myosin II Inhibitor

This study discovers and characterizes skeletostatins, selective skeletal myosin II inhibitors with improved properties for research and drug development.

Dual mechanism estrogen receptor inhibitors

This paper develops dual-mechanism ER inhibitors that use two distinct targeting moieties to suppress ER activity in breast cancer cells and resistance models.

A Simple and Robust Cell Based Assay for the Discovery of Novel Cytokinesis Inhibitors

This paper develops a cell-based assay to identify cytokinesis inhibitors, showing reliable EC50 values and good separation between positive and negative controls.

Overcoming high nanopore basecaller error rates for DNA storage via basecaller-decoder integration and convolutional codes

The paper reduces nanopore DNA sequencing error rates by integrating a Viterbi decoder with a basecaller and using convolutional codes, achieving lower reading costs than existing methods.

Improved read/write cost tradeoff in DNA-based data storage using LDPC codes

This paper improves the read/write cost tradeoff in DNA-based storage by using a single LDPC code for both erasure and error correction, achieving 30-40% lower reading costs on experimental data.

Quantitative Structural Assessment of Graded Receptor Agonism

The paper quantifies how agonist structure affects PPARγ conformational changes, showing efficacy correlates with shifts toward active states detected by NMR.

Structural basis of altered potency and efficacy displayed by a major in vivo metabolite of the anti-diabetic PPARγ drug pioglitazone

This study compares the structure and function of pioglitazone and its metabolite 1-hydroxypioglitazone bound to PPARγ, showing reduced potency and efficacy of the metabolite.

A structural mechanism for directing inverse agonism of PPARγ

The paper shows how a phenyl-to-pyridyl substitution in PPARγ ligands converts an antagonist to an inverse agonist through a water-mediated hydrogen bond network involving Arg288.