Author

R. S. Heyderman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:host-pathogen & immune response· 5 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. M. Weight· 3 shared J. Reine· 3 shared J. S. Brown· 3 shared C. Solorzano· 2 shared C. Venturini· 2 shared C. Weight· 2 shared D. M. Ferreira· 2 shared E. Nikolaou· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

C. M. Weight

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Expansion of pneumococcal serotype 23F and 14 lineages with genotypic changes in capsule polysaccharide locus and virulence gene profiles post introduction of pneumococcal conjugate vaccine in Blantyre, Malawi

R. Cave, A. Kalizang'oma, C. Chaguza, T. S. Mwalukomo, A. Kamng'ona, C. Brown, J. Msefula, F. Bonomali, R. Nyirenda, T. D. Swarthout, B. Kwambana-Adams, N. French, R. S. Heyderman

The paper analyzes whole-genome sequences of pneumococcal isolates in Malawi to show expansion of vaccine serotype lineages with genetic changes in capsule and virulence genes post-PCV13 introduction.

bioRxiv · Mar 25, 2024Microbiology

Bacterial surface lipoproteins mediate epithelial microinvasion by Streptococcus pneumoniae

J. M. Chan, E. Ramos-Sevillano, M. Betts, H. U. Wilson, C. M. Weight, A. Houhou-Ousalah, G. Pollara, J. S. Brown, R. S. Heyderman

This study investigates how pneumococcal lipoproteins mediate epithelial microinvasion and finds that differential lipoprotein repertoires do not significantly impact microinvasion, suggesting post-translational modifications may be responsible.

bioRxiv · Oct 18, 2023 · PreprintMicrobiology

Disease-attenuated pneumococcal biosynthesis gene mutants invade the mucosal epithelium and induce innate immunity

C. M. Weight, G. M. Pollara, M. Betts, R. Ragazzini, M. Connor, E. Ramos-Sevillano, J. Reine, M. Whelan, J. A. Guerra-Assuncao, P. Bonfanti, C. Jolly, M. Noursadeghi, D. Ferreira, J. Brown, R. S. Heyderman

This paper shows that disease-attenuated pneumococcal mutants retain epithelial microinvasion but show reduced transmigration and altered inflammatory responses.

bioRxiv · Jun 15, 2023Microbiology

The histone demethylase KDM6B fine-tunes the host response to Streptococcus pneumoniae.

M. G. Connor, T. M. N. Camarasa, E. Patey, O. Rasid, L. Barrio, C. Weight, D. P. Miller, R. S. HEYDERMAN, R. J. Lamont, J. Enninga, M. A. Hamon

This study shows that KDM6B modulates the host response to Streptococcus pneumoniae by altering chromatin structure at the IL-11 promoter, affecting NF-κB activation.

bioRxiv · May 28, 2020Microbiology

Epithelial micro-invasion by Streptococcus pneumoniae induces epithelial-derived innate immunity during colonisation at the human mucosal surface

C. M. Weight, C. Venturini, S. Pojar, S. Jochems, J. Reine, E. Nikolaou, C. Solorzano, M. Noursadeghi, J. S. Brown, D. M. Ferreira, R. S. Heyderman

This study shows that Streptococcus pneumoniae colonizes human mucosa via microinvasion, triggering epithelial innate immunity and influencing bacterial clearance.

Nature Communications · Jul 16, 2019Peer-reviewedImmunology

Defining mucosal immunity using mass cytometry following experimental human pneumococcal challenge

S. P. Jochems, K. de Ruiter, C. Solorzano, A. Voskamp, E. Mitsi, E. Nikolaou, B. F. Carniel, S. Pojar, E. German, J. Reine, A. Soares-Schanoski, H. Hill, R. Robinson, A. D. Hyder-Wright, C. Weight, , D. M. Ferreira

The paper uses mass cytometry to analyze nasal immune cells after pneumococcal challenge, identifying immune changes linked to colonization and host-pathogen interactions.

bioRxiv · Feb 11, 2019Immunology

Both the inflammatory response and clinical outcome differ markedly between adults with pneumococcal and meningococcal meningitis in a high HIV-1 prevalent setting in sub-Saharan Africa

E. C. Wall, J. A. Guerra-Assuncao, B. Denis, M. Scarborough, K. Ajdukiewicz, K. Cartwright, M. Mukaka, V. S. Mlozowa, C. Venturini, T. J. Allain, D. G. Lalloo, J. S. Brown, S. B. Gordon, R. S. Heyderman

This study compares inflammatory responses and clinical outcomes between pneumococcal and meningococcal meningitis in HIV-high prevalence settings, finding worse outcomes in pneumococcal cases.

bioRxiv · Feb 3, 2019 · PreprintImmunology