Author

C. Connor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 6 Assay:whole-genome sequencing· 5 Research Focus:chromatin & epigenetic regulation· 4 Approach:statistical model· 4 Approach:experimental assay· 3 Approach:comparative / phylogenetic analysis· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

A. McNally· 6 shared E. Cummins· 2 shared J. Corander· 2 shared R. J. Hall· 2 shared A. J. Church· 1 shared A. L. Hong· 1 shared A. Sayeed· 1 shared A. Snaith· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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6 shared papersMicrobiology

A. McNally

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Loss of type VI secretion systems in multi-drug resistant Escherichia coli clones

E. Cummins, R. Moran, A. Snaith, R. Hall, C. Connor, S. Dunn, A. McNally

This study investigates the loss of type VI secretion systems (T6SS) in multi-drug resistant (MDR) Escherichia coli clones and finds that essential T6SS genes are lost in multiple MDR clades through recombination and insertion events.

bioRxiv · Mar 28, 2023 · PreprintMicrobiology

Multi-drug resistant E. coli displace commensal E. coli from the intestinal tract, a trait associated with elevated levels of genetic diversity in carbohydrate metabolism genes.

C. Connor, A. Zucoloto, I. L. Yu, J. Corander, B. McDonald, A. McNally

This study shows that multi-drug resistant E. coli outcompetes non-MDR E. coli in the gut, linked to higher genetic diversity in carbohydrate metabolism genes.

bioRxiv · Nov 25, 2022 · PreprintMicrobiology

Pangenome evolution in Escherichia coli is sequence type, not phylogroup, specific

E. Cummins, R. J. Hall, C. Connor, J. McInerney, A. McNally

The paper compares pangenomes of different Escherichia coli sequence types to show that pangenome evolution is influenced by sequence type-specific factors rather than phylogroup relationships.

bioRxiv · May 20, 2022 · PreprintMicrobiology

Gene-gene relationships in an Escherichia coli accessory genome are linked to function and mobility

R. J. Hall, F. J. Whelan, E. A. Cummins, C. Connor, A. McNally, J. O. McInerney

This study identifies gene-gene relationships in an Escherichia coli accessory genome, showing that co-occurrence is driven by function and mobility.

bioRxiv · Mar 26, 2021Evolutionary Biology

Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition

A. L. Hong, Y.-Y. Tseng, J. A. Wala, W. J. Kim, B. D. Kynnap, M. B. Doshi, G. Kugener, G. J. Sandoval, T. P. Howard, J. Li, X. Yang, M. Tillgren, M. Ghandi, A. Sayeed, R. Deasy, , W. Hahn

This study identifies SMARCB1 loss as critical for RMC survival and shows proteasome inhibition as a potential therapeutic strategy.

bioRxiv · Dec 5, 2018Cancer Biology

Signatures of negative frequency dependent selection in colonisation factors and the evolution of a multi-drug resistant lineage of Escherichia coli

A. McNally, T. Kallonen, C. Connor, K. Abudahab, D. Aanensen, C. Horner, S. Peacock, J. Parkhill, N. Croucher, J. Corander

This study identifies negative frequency-dependent selection in Escherichia coli ST131 as a key driver of its evolutionary success and adaptation to different ecological niches.

bioRxiv · Nov 29, 2018 · PreprintMicrobiology

Complete genomic characterisation of two Escherichia coli lineages responsible for a cluster of carbapenem resistant infections in a Chinese hospital

Z. Zong, F. Yu, C. Connor, S. Fenn, A. McNally

The paper characterizes two E. coli lineages, ST167 and ST617, responsible for carbapenem-resistant infections, revealing their genomic evolution and resistance mechanisms.

bioRxiv · Jan 10, 2018Microbiology