Author

N. Croucher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Organism:E. coli· 1

Frequent Co-Authors

J. Corander· 3 shared A. McNally· 1 shared A. Vieira· 1 shared B. J. Arnold· 1 shared C. Colijn· 1 shared C. Connor· 1 shared C. Fraser· 1 shared C. Horner· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersEvolutionary Biology

J. Corander

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Characterization of the RofA regulon in the pandemic M1global and emergent M1UK lineages of Streptococcus pyogenes

X. Zhi, A. Vieira, K. K. Huse, P. J. Martel, L. Lobkowicz, H. K. Li, N. Croucher, I. Andrew, L. Game, S. Sriskandan

This study characterizes the RofA regulon in two emm1 lineages of Streptococcus pyogenes, showing lineage-specific gene expression changes and potential regulatory impacts of SNPs in the PRD domain.

bioRxiv · Jul 23, 2023 · PreprintMicrobiology

Predicting evolution using frequency-dependent selection in bacterial populations

T. Azarian, P. P. P. Martinez, B. J. Arnold, L. R. Grant, J. Corander, C. Fraser, N. Croucher, L. Hammitt, R. Reed, M. Santosham, R. R. Weatherholtz, S. D. Bentley, K. L. O'Brien, M. Lipsitch, W. P. Hanage

The paper predicts changes in pneumococcal populations after vaccination by analyzing accessory gene frequencies under negative frequency-dependent selection.

bioRxiv · Feb 25, 2020 · PreprintEvolutionary Biology

Designing ecologically-optimised vaccines using population genomics

C. Colijn, J. Corander, N. Croucher

This paper shows that vaccines designed using population genomics and ecological models can better reduce IPD and antibiotic-resistant disease by preventing serotype replacement.

bioRxiv · Jun 17, 2019Evolutionary Biology

Signatures of negative frequency dependent selection in colonisation factors and the evolution of a multi-drug resistant lineage of Escherichia coli

A. McNally, T. Kallonen, C. Connor, K. Abudahab, D. Aanensen, C. Horner, S. Peacock, J. Parkhill, N. Croucher, J. Corander

This study identifies negative frequency-dependent selection in Escherichia coli ST131 as a key driver of its evolutionary success and adaptation to different ecological niches.

bioRxiv · Nov 29, 2018 · PreprintMicrobiology