Author

Y.-Y. Tseng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:whole-exome sequencing· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

J. S. Boehm· 3 shared A. L. Hong· 2 shared B. D. Kynnap· 2 shared C. M. Clinton· 2 shared D. E. Root· 2 shared E. A. Mullen· 2 shared K. L. Ligon· 2 shared P. C. Gokhale· 2 shared

Activity by Year

2016-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

J. S. Boehm

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Targeting TRIP13 in Wilms Tumor with Nuclear Export Inhibitors

K. Mittal, B. P. Lee, G. W. Cooper, J. Shim, H. C. Jonus, W. J. Kim, M. Doshi, D. Almanza, B. D. Kynnap, A. L. Christie, X. Yang, G. S. Cowley, B. A. Leeper, C. L. Morton, B. Dwivedi, , A. L. Hong

This study identifies XPO1 inhibition with selinexor as a potential therapy for favorable histology Wilms tumors, showing synergy with doxorubicin in preclinical models.

bioRxiv · Feb 23, 2022Cancer Biology

Viperin binds STING and enhances the type-I interferon response following dsDNA detection

K. M. Crosse, E. A. Monson, A. B. Dumbrepatil, M. Smith, Y.-Y. Tseng, K. H. Van der Hoek, P. A. Revill, D. C. Tscharke, E. N. G. Marsh, M. R. Beard, K. J. Helbig

This study identifies Viperin's role in enhancing the type-I interferon response by binding STING and promoting TBK1 ubiquitination, thereby strengthening antiviral immunity against dsDNA.

bioRxiv · Dec 17, 2019Immunology

Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition

A. L. Hong, Y.-Y. Tseng, J. A. Wala, W. J. Kim, B. D. Kynnap, M. B. Doshi, G. Kugener, G. J. Sandoval, T. P. Howard, J. Li, X. Yang, M. Tillgren, M. Ghandi, A. Sayeed, R. Deasy, , W. Hahn

This study identifies SMARCB1 loss as critical for RMC survival and shows proteasome inhibition as a potential therapeutic strategy.

bioRxiv · Dec 5, 2018Cancer Biology

Adenosine Deaminase Acting on RNA 1 Associates with Orf Virus OV20.0 and Enhances Viral Replication

G.-R. Liao, Y.-Y. Tseng, J.-Y. Tseng, F.-Y. Lin, Y. Yamada, H.-P. Liu, C.-Y. Kuan, W.-L. Hsu

This study identifies a novel interaction between ORFV protein OV20.0 and ADAR1, showing OV20.0 suppresses ADAR1's A-to-I editing and enhances viral replication by inhibiting PKR phosphorylation.

bioRxiv · Nov 1, 2018Microbiology

Patient-derived xenografts undergo murine-specific tumor evolution

U. Ben-David, G. Ha, Y.-Y. Tseng, N. F. Greenwald, C. Oh, J. Shih, J. M. McFarland, B. Wong, J. S. Boehm, R. Beroukhim, T. R. Golub

This study shows that PDX tumors acquire new genomic changes over passages, differ from human tumors, and affect drug responses.

bioRxiv · Jul 24, 2017Cancer Biology

Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration

A. M. Zaritsky, Y.-Y. Tseng, A. M. Rabadan, S. Krishna, M. Overholtzer, G. Danuser, A. Hall

The paper identifies GEFs regulating collective cell migration by screening human bronchial epithelial cells, showing RHOA GEFs influence intercellular communication and motility.

bioRxiv · Sep 21, 2016Cell Biology