Author

C. Demetriades

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:proteomics· 2 Approach:wet-lab / biochemical assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

F. Artoni· 2 shared G. Figlia· 2 shared J. Nuechel· 2 shared L. Brohee· 2 shared P. Gollwitzer· 2 shared S. A. Fernandes· 2 shared A. A. Teleman· 1 shared A. Kopach· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

F. Artoni

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Spatially and Functionally Distinct mTORC1 Entities Orchestrate the Cellular Response to Amino Acid Availability

S. A. Fernandes, D.-D. Angelidaki, J. Nuechel, J. Pan, P. Gollwitzer, Y. Elkis, F. Artoni, S. Wilhelm, M. Kovacevic-Sarmiento, C. Demetriades

This study reveals spatially and functionally distinct mTORC1 entities that regulate cellular responses to amino acid availability through lysosomal and non-lysosomal mechanisms.

bioRxiv · Oct 3, 2023 · PreprintCell Biology

Comprehensive Evaluation of the Specificity of Rapamycin as an mTOR Inhibitor

F. Artoni, N. Grutzmacher, C. Demetriades

This study evaluates rapamycin's specificity as an mTOR inhibitor using gene-edited cells, showing minimal off-target effects on transcriptome and proteome.

bioRxiv · Dec 10, 2022 · PreprintCell Biology

Malonyl-CoA is an ancient physiological ATP-competitive mTORC1 inhibitor

R. Nicastro, L. Brohee, J. Alba, J. Nuechel, G. Figlia, S. Kipschull, P. Gollwitzer, J. Romero-Pozuelo, S. A. Fernandes, A. Lamprakis, S. Vanni, A. A. Teleman, C. De Virgilio, C. Demetriades

The paper shows malonyl-CoA inhibits mTORC1 by competing with ATP, linking lipid biosynthesis to cellular growth regulation in yeast and mammals.

bioRxiv · Nov 6, 2022 · PreprintCell Biology

G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence of stress granules

M. T. Prentzell, U. Rehbein, M. Cadena Sandoval, A.-S. De Meulemeester, R. Baumeister, L. Brohee, B. Berdel, M. Bockwoldt, B. Carroll, A. von Deimling, C. Demetriades, G. Figlia, A. M. Heberle, I. Heiland, B. Holzwarth, , K. Thedieck

This paper shows G3BP1 anchors the TSC complex to lysosomes to suppress mTORC1 signaling without stress granules, and inhibits mTORC1-driven cancer and neuronal issues.

bioRxiv · Apr 16, 2020Cell Biology