Author

S. A. Fernandes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

C. Demetriades· 2 shared J. Nuechel· 2 shared P. Gollwitzer· 2 shared A. A. Teleman· 1 shared A. Lamprakis· 1 shared C. De Virgilio· 1 shared D.-D. Angelidaki· 1 shared F. Artoni· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCell Biology

C. Demetriades

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Author profile →

2 papers

Recent·Most cited

Spatially and Functionally Distinct mTORC1 Entities Orchestrate the Cellular Response to Amino Acid Availability

S. A. Fernandes, D.-D. Angelidaki, J. Nuechel, J. Pan, P. Gollwitzer, Y. Elkis, F. Artoni, S. Wilhelm, M. Kovacevic-Sarmiento, C. Demetriades

This study reveals spatially and functionally distinct mTORC1 entities that regulate cellular responses to amino acid availability through lysosomal and non-lysosomal mechanisms.

bioRxiv · Oct 3, 2023 · PreprintCell Biology

Malonyl-CoA is an ancient physiological ATP-competitive mTORC1 inhibitor

R. Nicastro, L. Brohee, J. Alba, J. Nuechel, G. Figlia, S. Kipschull, P. Gollwitzer, J. Romero-Pozuelo, S. A. Fernandes, A. Lamprakis, S. Vanni, A. A. Teleman, C. De Virgilio, C. Demetriades

The paper shows malonyl-CoA inhibits mTORC1 by competing with ATP, linking lipid biosynthesis to cellular growth regulation in yeast and mammals.

bioRxiv · Nov 6, 2022 · PreprintCell Biology