Author

C. De Virgilio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:yeast· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

R. Nicastro· 3 shared A. A. Teleman· 1 shared A. Lamprakis· 1 shared C. Demetriades· 1 shared E. Fernandez-Garcia· 1 shared F. Tripodi· 1 shared G. Figlia· 1 shared H. Gaillard· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

R. Nicastro

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Malonyl-CoA is an ancient physiological ATP-competitive mTORC1 inhibitor

R. Nicastro, L. Brohee, J. Alba, J. Nuechel, G. Figlia, S. Kipschull, P. Gollwitzer, J. Romero-Pozuelo, S. A. Fernandes, A. Lamprakis, S. Vanni, A. A. Teleman, C. De Virgilio, C. Demetriades

The paper shows malonyl-CoA inhibits mTORC1 by competing with ATP, linking lipid biosynthesis to cellular growth regulation in yeast and mammals.

bioRxiv · Nov 6, 2022 · PreprintCell Biology

Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation

M. Caligaris, R. Nicastro, Z. Hu, F. Tripodi, J. E. Hummel, M.-A. Deprez, J. Winderickx, S. Rospert, P. Coccetti, J. Dengjel, C. De Virgilio

This study shows Snf1/AMPK inhibits TORC1 during glucose starvation via Pib2 and Sch9 phosphorylation, integrating glucose and glutamine signals to regulate cell growth.

bioRxiv · Oct 18, 2022Biochemistry

Manganese is a Physiologically Relevant TORC1 Activator in Yeast and Mammals.

R. Nicastro, H. Gaillard, L. Zarzuela, M.-P. Peli-Gulli, E. Fernandez-Garcia, M. Tome, N. Garcia-Rodriguez, R. V. Duran, C. De Virgilio, R. E. Wellinger

This paper shows that manganese activates TORC1 in yeast and mammals, with implications for disease and aging.

bioRxiv · Dec 9, 2021Cell Biology