Author

R. Hussain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:proteomics· 3 Assay:scRNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. F. Hatton· 2 shared C. Ward· 2 shared I. J. Haq· 2 shared M. Brodlie· 2 shared M. Haniffa· 2 shared S. Hambleton· 2 shared A. Alkhalefah· 1 shared A. C. M. Khan· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

C. F. Hatton

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Author profile →

6 papers

Recent·Most cited

BCG activation of trained immunity is associated with induction of cross reactive COVID-19 antibodies in a BCG vaccinated population.

N. T. Iqbal, K. Ahmed, T. Sattar, F. Aziz, R. Hussain

The study examines BCG-induced trained immunity in adults, finding elevated cytokine responses and cross-reactive SARS-CoV-2 antibodies, suggesting potential cross-protection against COVID-19.

bioRxiv · Jan 2, 2024Immunology

BBIBP-CorV (Sinopharm) vaccination- induced immunity is affected by age, gender and prior COVID-19 and activates responses to spike and other antigens

Z. Hasan, K. I. Masood, S. Qaiser, E. Khan, A. Hussain, Z. Ghous, U. Khan, M. Yameen, I. Hassan, M. I. Nisar, M. F. Qazi, H. A. Memon, S. Ali, S. Baloch, Z. A. Bhutta, , K. Ghias

This study examines how BBIBP-CorV vaccination-induced immunity varies with age, gender, and prior COVID-19, showing differential antibody and T cell responses to SARS-CoV-2 antigens.

bioRxiv · Nov 30, 2022 · PreprintImmunology

Conjunctival epithelial cells resist productive SARS-CoV-2 infection

M. Lako, R. M. Jackson, C. F. Hatton, J. S. Spegarova, M. Georgiou, J. Collin, E. Stephenson, B. Vernon, I. J. Haq, R. Hussain, J. M. Coxhead, H. S. Mudhar, B. Wagner, M. Hasoon, T. Davie, , C. J. Duncan

The paper investigates whether conjunctival epithelial cells can be infected by SARS-CoV-2 and finds that while genome expression occurs, productive infection does not.

bioRxiv · Dec 20, 2021Cell Biology

Impact of maternal intermittent fasting during pregnancy on cardiovascular, metabolic and renal function in adult rat offspring

A. Alkhalefah, H. J. Eyre, R. Hussain, J. D. Glazier, N. Ashton

This study examines the effects of maternal intermittent fasting during pregnancy on adult rat offspring's cardiovascular, metabolic, and renal function, finding no significant differences in baseline metrics but increased renal injury in males under salt challenge.

bioRxiv · Sep 27, 2021Physiology

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2

C. F. Hatton, R. A. Botting, M. E. Duenas, I. J. Haq, B. Verdon, B. J. Thompson, J. Stremenova Spegarova, F. Gothe, E. A. Stephenson, A. I. Gardner, S. Murphy, J. Scott, J. P. Garnett, S. Carrie, J. Powell, , C. J. A. Duncan

This study shows that delayed type I and III interferon responses in nasal epithelial cells allow SARS-CoV-2 replication, but pre-infection IFN treatment restricts virus and preserves barrier integrity.

bioRxiv · Feb 17, 2021Immunology

CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity

N. Manouchehri, R. Hussain, P. Cravens, B. Edelson, G. Wu, A. Cross, R. Doelger, N. Loof, T. Eagar, T. Forsthuber, L. Calvier, J. Herz, O. Stuve

This study identifies CD11c+CD88+CD317+ myeloid cells as key drivers of CNS autoimmunity and shows that targeting these cells with anti-CD317 mAb reduces disease.

bioRxiv · Jun 10, 2020Immunology