W. S. James

Analysis of emergent bivalent antibody binding identifies the molecular reach as a critical determinant of SARS-CoV-2 neutralisation potency

This paper develops a bivalent binding model to analyze how molecular reach affects SARS-CoV-2 neutralization potency across antibodies.

Multiviral Quartet Nanocages Elicit Broad Anti-Coronavirus Responses for Proactive Vaccinology

A vaccine candidate with polyprotein antigens displayed on nanocages induces neutralizing antibodies to multiple SARS-like coronaviruses.

SAMHD1 controls nucleoside-based cancer therapeutics, deoxyguanosine toxicity, and inflammation

This study shows that SAMHD1 knockout affects nucleoside analogue sensitivity, deoxyguanosine toxicity, and inflammation in macrophages, linking it to Acardi-Goutieres Syndrome and cancer therapies.

Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSCs to microglia

The paper identifies redundant medium components in iPSC differentiation to microglia using single-cell RNA sequencing and provides an optimized protocol for generating functional microglia.

Type I interferons govern Zika virus resistance of human macrophages and microglia

This study shows that type I interferons restrict Zika virus replication in macrophages and microglia, and their suppression increases viral replication and cell damage.

Naturally-acquired immunity in Syrian Golden Hamsters provides protection from re-exposure to emerging heterosubtypic SARS-CoV-2 variants B.1.1.7 and B.1.351

This study shows that prior SARS-CoV-2 infection in Syrian Golden Hamsters protects against re-exposure to variants B.1.1.7 and B.1.351, suggesting immunity may limit disease from emerging variants.

Differentiation of Human induced Pluripotent Stem Cells to Authentic Macrophages using Fully Defined, Serum Free, Open Source Media

This paper describes two fully defined, serum-free, open-source media for culturing human iPSCs and differentiating them into macrophages, showing improved characteristics compared to commercial media.

Plasmablast-derived antibody response to acute SARS-CoV-2 infection in humans

This study analyzes plasmablast-derived antibodies in three COVID-19 patients, identifying neutralizing antibodies and cross-reactivity with other betacoronaviruses.

A novel biparatopic antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

This paper identifies an antibody, EY6A, from a convalescent patient that neutralizes SARS-CoV-2 and cross-reacts with SARS-CoV-1 by binding a conserved epitope on the Spike protein.

A chemical tool for improved culture of human pluripotent stem cells

This paper identifies a small molecule, OXS8360, that improves the culture of human pluripotent stem cells by disrupting cell-cell contacts without affecting pluripotency or differentiation.

LRRK2 is recruited to phagosomes and co-recruits Rab8 and Rab10 in human pluripotent stem cell-derived macrophages

This study shows LRRK2 is recruited to maturing phagosomes and required for Rab8a and Rab10 recruitment in human macrophages.