Author

C. G. Dowson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:bacteria (other)· 1 Organism:E. coli· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

A. J. Lloyd· 3 shared D. I. Roper· 3 shared D. Bellini· 2 shared A. Aimon· 1 shared A. Bradley· 1 shared A. C. Cuming· 1 shared A. Douangamath· 1 shared A. J. Dowson· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

A. J. Lloyd

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Discovery and chemical optimisation of a Potent, Bi-cyclic (Bicycle(R)) Antimicrobial Inhibitor of Escherichia coli PBP3

C. E. Rowland, H. Newman, T. T. Martin, R. Dods, N. Bournakas, J. M. Wagstaff, N. Lewis, S. J. Stanway, M. Balmforth, C. Kessler, K. van Rietschoten, D. Bellini, D. I. Roper, A. J. Lloyd, C. G. Dowson, , M. J. Dawson

This study discovers and optimizes bicyclic peptide inhibitors of E. coli PBP3, showing high-affinity binding and broad-spectrum antimicrobial activity.

bioRxiv · Mar 20, 2024 · PreprintBiochemistry

Plant peptidoglycan precursor biosynthesis: Conservation between moss chloroplasts and Gram negative bacteria

A. J. Dowson, A. J. Lloyd, A. C. Cuming, D. I. Roper, L. Frigerio, C. G. Dowson

The paper identifies conserved peptidoglycan biosynthesis intermediates in moss chloroplasts and demonstrates D,L-DAP incorporation by a moss enzyme similar to Gram-negative bacteria.

Plant Physiology · Apr 26, 2022Peer-reviewedEvolutionary Biology

Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase

R. Cain, R. Salimaraj, A. S. Punekar, D. Bellini, C. W. G. Fishwisk, L. Czapleski, D. J. Scott, G. Harris, C. G. Dowson, A. J. Lloyd, D. I. Roper

The paper identifies small molecule inhibitors that selectively target bacterial seryl-tRNA synthetases over human homologues using structure-based drug discovery.

bioRxiv · Mar 22, 2019Biochemistry

Rapid covalent-probe discovery by electrophile fragment screening

e. resnick, A. Bradley, J. Gan, A. Douangamath, T. Krojer, R. Sethi, A. Aimon, G. Amitai, D. Belini, J. Bennett, M. Fairhead, O. Fedorov, P. P. Geurink, J. Guo, A. Plotnikov, , N. London

This study develops a method for discovering covalent probes using electrophile fragment screening and identifies selective inhibitors for OTUB2 and NUDT7.

bioRxiv · Oct 14, 2018Biochemistry