Author

R. Cain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. J. Lloyd· 1 shared A. S. Punekar· 1 shared B. O. Anonye· 1 shared C. A. Ortori· 1 shared C. Corre· 1 shared C. G. Dowson· 1 shared C. Lee· 1 shared C. W. G. Fishwisk· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

A. J. Lloyd

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2 papers

Recent·Most cited

Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients.

J. Furner-Pardoe, B. O. Anonye, R. Cain, J. Moat, C. A. Ortori, C. Lee, D. A. Barrett, C. Corre, F. Harrison

This paper shows a medieval remedy containing onion, garlic, wine, and bile salts has anti-biofilm activity against multiple pathogens, but requires all ingredients to work effectively.

Scientific Reports · Jul 28, 2020Peer-reviewedMicrobiology

Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase

R. Cain, R. Salimaraj, A. S. Punekar, D. Bellini, C. W. G. Fishwisk, L. Czapleski, D. J. Scott, G. Harris, C. G. Dowson, A. J. Lloyd, D. I. Roper

The paper identifies small molecule inhibitors that selectively target bacterial seryl-tRNA synthetases over human homologues using structure-based drug discovery.

bioRxiv · Mar 22, 2019Biochemistry