Author

D. I. Roper

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:E. coli· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:metabolomics· 1 Organism:mouse· 1 Assay:structural biology· 1

Frequent Co-Authors

A. J. Lloyd· 3 shared C. G. Dowson· 3 shared D. Bellini· 2 shared A. C. Cuming· 1 shared A. J. Dowson· 1 shared A. S. Punekar· 1 shared C. E. Rowland· 1 shared C. Kessler· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

A. J. Lloyd

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Discovery and chemical optimisation of a Potent, Bi-cyclic (Bicycle(R)) Antimicrobial Inhibitor of Escherichia coli PBP3

C. E. Rowland, H. Newman, T. T. Martin, R. Dods, N. Bournakas, J. M. Wagstaff, N. Lewis, S. J. Stanway, M. Balmforth, C. Kessler, K. van Rietschoten, D. Bellini, D. I. Roper, A. J. Lloyd, C. G. Dowson, , M. J. Dawson

This study discovers and optimizes bicyclic peptide inhibitors of E. coli PBP3, showing high-affinity binding and broad-spectrum antimicrobial activity.

bioRxiv · Mar 20, 2024 · PreprintBiochemistry

Structural insights into peptidoglycan hydrolysis by the FtsEX system in Escherichia coli during cell division

J. Li, Y. He, X. Xu, M. Alcorlo, J. Shi, S. Naskar, N. Briggs, D. I. Roper, J. A. Hermoso, L.-T. Sham, M. Luo

This study presents structural and biochemical analysis of E. coli FtsEX complex, revealing ATP's role in stabilization and EnvC-mediated activation of PG hydrolysis.

bioRxiv · Jan 16, 2024 · PreprintMicrobiology

Plant peptidoglycan precursor biosynthesis: Conservation between moss chloroplasts and Gram negative bacteria

A. J. Dowson, A. J. Lloyd, A. C. Cuming, D. I. Roper, L. Frigerio, C. G. Dowson

The paper identifies conserved peptidoglycan biosynthesis intermediates in moss chloroplasts and demonstrates D,L-DAP incorporation by a moss enzyme similar to Gram-negative bacteria.

bioRxiv · Jan 5, 2022Evolutionary Biology

Structure-guided enhancement of selectivity of chemical probe inhibitors targeting bacterial seryl-tRNA synthetase

R. Cain, R. Salimaraj, A. S. Punekar, D. Bellini, C. W. G. Fishwisk, L. Czapleski, D. J. Scott, G. Harris, C. G. Dowson, A. J. Lloyd, D. I. Roper

The paper identifies small molecule inhibitors that selectively target bacterial seryl-tRNA synthetases over human homologues using structure-based drug discovery.

bioRxiv · Mar 22, 2019Biochemistry