C. Guillonneau

Combinatory differentiation of human induced pluripotent stem cells generates thymic epithelium that supports thymic crosstalk and directs dendritic- and CD4/CD8 T-cell full development

This study generates functional thymic epithelial cells from iPSCs that support T cell development and dendritic cell differentiation in vitro.

Single cell analysis reveals CD45RClow/-TNFR2+CD29lowCD8+ Tregs with superior activity

The paper identifies and characterizes three subsets of human CD8+ regulatory T cells using single-cell CITE-seq and VDJ sequencing, highlighting a subset with superior suppressive activity.

IL-34 deficiency impairs FOXP3+ Treg function and increases susceptibility to autoimmunity

This study shows IL-34 deficiency impairs FOXP3+ Treg function, leading to autoimmunity and increased susceptibility to colitis and graft rejection.

CD4+ and CD8+ regulatory T cells characterization in the rat using a unique transgenic Foxp3-EGFP model.

The paper develops a rat transgenic model with Foxp3-EGFP to study CD4+ and CD8+ regulatory T cells, revealing their frequencies, markers, suppressive activity, and transcriptome.

Immunological characterization of a rat model of Duchenne’s disease and demonstration of improved muscle strength after anti-CD45RC antibody treatment

This study characterizes immune responses in a rat model of Duchenne’s disease and shows that anti-CD45RC antibody treatment improves muscle strength without side effects.