I. Anegon

Single cell analysis reveals CD45RClow/-TNFR2+CD29lowCD8+ Tregs with superior activity

The paper identifies and characterizes three subsets of human CD8+ regulatory T cells using single-cell CITE-seq and VDJ sequencing, highlighting a subset with superior suppressive activity.

Changes in social behaviour with alterations of MAPK3 and KCTD13/CUL3 pathways in two new outbred rat models for the 16p11.2 syndromes with autism spectrum disorders.

This paper creates two rat models with 16p11.2 CNVs to study social behavior and finds altered MAPK3 and CUL3 pathways with sexual dimorphism in phenotypes.

Cryopreserved cGMP-compliant human pluripotent stem cells-derived immature hepatic progenitors rescue mice from acute liver failure

IL-34 deficiency impairs FOXP3+ Treg function and increases susceptibility to autoimmunity

This study shows IL-34 deficiency impairs FOXP3+ Treg function, leading to autoimmunity and increased susceptibility to colitis and graft rejection.

CD4+ and CD8+ regulatory T cells characterization in the rat using a unique transgenic Foxp3-EGFP model.

The paper develops a rat transgenic model with Foxp3-EGFP to study CD4+ and CD8+ regulatory T cells, revealing their frequencies, markers, suppressive activity, and transcriptome.

Highly Efficient Knockin in Human iPS Cells and Rat Embryos by CRISPR/Cas9 Molecular Optimization

This study optimizes CRISPR/Cas9 reagent concentrations for efficient knockin in human iPS cells and rat embryos, achieving 50% knockin efficiency with reduced costs and toxicity.

A new variant of ASIC2 mediates sodium retention in nephrotic syndrome

The paper identifies a truncated variant of ASIC2b responsible for sodium retention in idiopathic nephrotic syndrome, independent of ENaC and aldosterone.

Immunological characterization of a rat model of Duchenne’s disease and demonstration of improved muscle strength after anti-CD45RC antibody treatment

This study characterizes immune responses in a rat model of Duchenne’s disease and shows that anti-CD45RC antibody treatment improves muscle strength without side effects.