Author

T. Larcher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Pathology· 2 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:host-pathogen & immune response· 6 Approach:experimental assay· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Suhrbier· 4 shared B. Tang· 4 shared C. R. Bishop· 4 shared D. J. Rawle· 4 shared K. Yan· 4 shared W. Nguyen· 3 shared R. Stewart· 2 shared A. A. Khromykh· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

A. Suhrbier

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease

A. Carolin, D. Frazer, K. Yan, C. R. Bishop, B. Tang, W. Nguyen, S. L. Helman, J. Horvat, T. Larcher, D. J. Rawle, A. Suhrbier

This study investigates the effects of iron deficiency and overload on SARS-CoV-2 lung infection in mice, finding modest inflammatory changes but no significant disease exacerbation.

bioRxiv · May 29, 2024Pathology

Microplastics dysregulate innate immunity in the SARS-CoV-2 infected lung

C. R. Bishop, D. J. Rawle, K. Yan, B. Tang, T. Larcher, A. Suhrbier

This study shows that microplastics co-delivered with SARS-CoV-2 in mice suppress early innate immune responses but promote a cytokine release syndrome signature later in infection.

bioRxiv · Nov 19, 2023Microbiology

Neurovirulence of the Australian outbreak Japanese Encephalitis virus genotype 4 is lower compared to genotypes 2 and 3 in mice and human cortical brain organoids

W. Nguyen, N. Gyawali, R. Stewart, B. Tang, A. L. Cox, K. Yan, T. Larcher, C. R. Bishop, N. Wood, G. Devine, A. Suhrbier, D. J. Rawle

This study compares the neurovirulence of JEV genotype 4 (JEVNSW/22) with genotypes 2 and 3 in mice and human brain organoids, finding JEVNSW/22 less neurovirulent and more sensitive to type I interferon.

bioRxiv · Apr 26, 2023 · PreprintMicrobiology

Increased neurovirulence of omicron BA.5 and XBB variants over BA.1 in K18-hACE2 mice and human brain organoids

R. Stewart, K. Yan, S. A. Ellis, C. R. Bishop, T. Dumenil, B. Tang, W. Nguyen, T. Larcher, R. Parry, J. D. J. Sng, A. A. Khromykh, R. K. P. Sullivan, M. Lor, F. A. Meunier, D. J. Rawle, A. Suhrbier

This study shows that omicron BA.5 and XBB variants are more neurovirulent than BA.1 in mice and human brain organoids, leading to increased brain infection and mortality.

bioRxiv · Dec 22, 2022 · PreprintMicrobiology

New look at RSV infection : tissue clearing and 3D imaging of the entire mouse lung at cellular resolution.

M. Fretaud, D. Descamps, D. Laubreton, M.-A. Rameix-Welti, J. F. Eleouet, T. Larcher, M. Galloux, C. langevin

This study uses tissue clearing and 3D imaging to visualize RSV infection in whole mouse lungs, identifying infected cell subtypes and viral inclusion bodies.

bioRxiv · Dec 23, 2020Pathology

Immunological characterization of a rat model of Duchenne’s disease and demonstration of improved muscle strength after anti-CD45RC antibody treatment

L.-H. Ouisse, S. Remy, A. Lafoux, T. Larcher, L. Tesson, V. Chenouard, C. Guillonneau, L. Brusselle, N. Vimond, K. Rouger, Y. Pereon, A. Chenouard, C. Gras-Le Guen, C. Braudeau, R. Josien, , I. Anegon

This study characterizes immune responses in a rat model of Duchenne’s disease and shows that anti-CD45RC antibody treatment improves muscle strength without side effects.

bioRxiv · Sep 3, 2018Immunology