Author

A. Krook

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 6 Biochemistry· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 9 Assay:bulk RNA-seq· 7 Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Research Focus:differential expression· 4 Research Focus:metabolism & bioenergetics· 4 Research Focus:chromatin & epigenetic regulation· 3 Assay:metabolomics· 3

Frequent Co-Authors

J. R. Zierath· 10 shared B. M. Gabriel· 4 shared N. J. Pillon· 4 shared A. V. Chibalin· 3 shared D. Rizo-Roca· 3 shared J. A. B. Smith· 3 shared L. Sardon Puig· 3 shared M. Ryden· 3 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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10 shared papersPhysiology

J. R. Zierath

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10 papers

Recent·Most cited

Human-specific lncRNA TMEM9B-AS1 is downregulated in skeletal muscle of individuals with type 2 diabetes and regulates ribosomal biogenesis

I. Sen, J. A. B. Smith, E. Caria, M. Savikj, K. Lian, S. Ellefsen, J. R. Zierath, A. Krook

This study identifies TMEM9B-AS1, a human-specific lncRNA downregulated in type 2 diabetes skeletal muscle, which regulates ribosomal biogenesis by stabilizing MYC mRNA through interaction with IGF2BP1.

bioRxiv · Jul 5, 2024 · PreprintCell Biology

Downregulation of NR4A3 during inactivity alters glucose metabolism and impairs translation in human skeletal muscle

J. A. Smith, B. M. Gabriel, A. M. Abdelmoez, M. Savikj, S. C. Wright, S. Koutsilieri, R. Barres, V. M. Lauschke, A. Krook, J. R. Zierath, N. J. Pillon

This study shows that reduced NR4A3 levels in skeletal muscle due to inactivity impair glucose metabolism, translation, and myotube size by affecting mTORC1 and ribosomal pathways.

bioRxiv · Mar 11, 2024 · PreprintCell Biology

Personalized Molecular Signatures of Insulin Resistance and Type 2 Diabetes

J. Larsen, B. Stocks, J. Henderson, D. Andersson, J. Backdahl, D. Eriksson-Hogling, J. Stidsen, K. Sakamoto, K. Hojlund, M. Ryden, J. R. Zierath, A. Krook, A. S. Deshmukh

The paper uses proteomics to identify personalized signatures of insulin resistance and type 2 diabetes, showing that fasting proteome and phosphoproteome predict insulin sensitivity and reveal sex-specific differences.

bioRxiv · Feb 6, 2024 · PreprintBiochemistry

Decreased sarcomeric mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin action in type 2 diabetes

D. Rizo-Roca, D. S. Guimaraes, L. A. Pendergrast, N. Di Leo, A. V. Chibalin, S. Maqdasy, M. Ryden, E. Naslund, J. R. Zierath, A. Krook

The paper shows that reduced CKMT2 impairs mitochondrial function in type 2 diabetes, independent of insulin action.

bioRxiv · Jan 11, 2024 · PreprintPhysiology

Inhibition of mammalian mtDNA transcription paradoxically activates liver fatty acid oxidation to reverse diet-induced hepatosteatosis and obesity

S. Jiang, T. Yuan, L. S. Kremer, F. A. Rosenberger, F. M. Hansen, M. Borg, D. Rubalcava-Gracia, M. Mennuni, R. Filograna, D. Alsina, J. Misic, C. Koolmeister, L. Ren, O. Andersson, A. Unger, , N.-G. Larsson

The paper shows that inhibiting mitochondrial DNA transcription in mice increases fatty acid oxidation, reducing obesity and liver fat while decreasing oxidative phosphorylation capacity.

bioRxiv · Sep 22, 2023 · PreprintPhysiology

Concerted regulation of skeletal muscle metabolism and contractile properties by the orphan nuclear receptor Nr2f6

D. S. P. S. F. Guimaraes, N. M. F. Barrios, A. G. de Oliveira, D. Rizo-Roca, M. Jollet, J. A. B. Smith, T. R. Araujo, M. V. da Cruz, A. S. Vieira, S. M. Hirabara, E. Marconato, A. Krook, J. R. Zierath, L. d. R. Silveira

This study investigates Nr2f6's role in skeletal muscle by showing it regulates metabolism, contractile properties, and cell cycle, with effects conserved across species.

bioRxiv · May 17, 2023Biochemistry

Disrupted circadian core-clock oscillations in Type 2 Diabetes are linked to altered rhythmic mitochondrial metabolism

B. M. Gabriel, A. Altintas, J. A. B. Smith, L. Sardon Puig, X. Zhang, A. Linde Basse, R. C. Laker, H. Gao, Z. Liu, L. Dollet, J. T. Treebak, A. Zorzano, Z. Huo, M. Ryden, J. T. Lanner, , J. R. Zierath

bioRxiv · Feb 24, 2021Physiology

Saturated Fat Impairs Circadian Transcriptomics through Histone Modification of Enhancers

N. J. Pillon, L. Sardon Puig, A. Altintas, P. G. Kamble, S. Casani-Galdon, B. M. Gabriel, R. Barres, A. Conesa, A. V. Chibalin, E. Naslund, A. Krook, J. R. Zierath

The paper shows that palmitate disrupts circadian transcriptomic rhythmicity in skeletal muscle by altering histone H3K27ac modification of enhancers.

bioRxiv · Feb 23, 2021 · PreprintPhysiology

Branched-Chain Amino Acid Metabolism is Regulated by ERRα in Primary Human Myotubes and is Further Impaired by Glucose Loading in Type 2 Diabetes

R. J. O. Sjögren, D. Rizo-Roca, A. V. Chibalin, E. Chorell, R. Furrer, S. Katayama, J. Harada, H. K. R. Karlsson, C. Handschin, T. Moritz, A. Krook, E. Näslund, J. R. Zierath

This study shows that type 2 diabetes impairs BCAA catabolism, which is regulated by ERRα via PGC-1 in human myotubes, and glucose loading worsens this impairment.

bioRxiv · Jul 24, 2020Physiology

Transcriptomic Profiling of Skeletal Muscle Adaptations to Exercise and Inactivity

N. J. Pillon, B. M. Gabriel, L. Dollet, J. Smith, L. Sardon Puig, J. Botella, D. J. Bishop, A. Krook, J. R. Zierath

This study uses meta-analysis of 66 datasets to identify gene expression changes in skeletal muscle due to exercise and inactivity, highlighting NR4A3 as a key responsive gene.

bioRxiv · Oct 22, 2019Physiology