J. R. Zierath

The paper shows that inhibiting mitochondrial DNA transcription in mice increases fatty acid oxidation, reducing obesity and liver fat while decreasing oxidative phosphorylation capacity.

This study investigates Nr2f6's role in skeletal muscle by showing it regulates metabolism, contractile properties, and cell cycle, with effects conserved across species.

The paper shows that palmitate disrupts circadian transcriptomic rhythmicity in skeletal muscle by altering histone H3K27ac modification of enhancers.

This study examines the methylome and transcriptome changes in human skeletal muscle after high-intensity sprint exercise, finding that change of direction exercise causes greater epigenetic and gene expression changes than straight line sprinting.

This study shows that type 2 diabetes impairs BCAA catabolism, which is regulated by ERRα via PGC-1 in human myotubes, and glucose loading worsens this impairment.

This study uses meta-analysis of 66 datasets to identify gene expression changes in skeletal muscle due to exercise and inactivity, highlighting NR4A3 as a key responsive gene.