Author

C. Hinze

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Kennedy· 2 shared D. Sansom· 2 shared S. Dovedi· 2 shared C. Dittmayer· 1 shared C. Lloyd· 1 shared C. T. Orozco· 1 shared C. Williams· 1 shared D. E. Yilmaz· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

A. Kennedy

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80 / PD-L1 interaction

M. A. Robinson, A. Kennedy, C. T. Orozco, H.-C. Chen, E. A. Waters, D. Giovacchini, K. Yeung, L. Filer, C. Hinze, C. Lloyd, S. Dovedi, D. Sansom

This paper shows that rigid, bivalent CTLA-4 binding to CD80 disrupts the cis CD80/PD-L1 interaction, promoting PD-L1 availability through orientation and cross-linking.

bioRxiv · Apr 19, 2024 · PreprintImmunology

Immunosuppression with Cyclosporine versus Tacrolimus shows distinctive nephrotoxicity profiles within renal compartments

H. Demirci, S. Popovic, C. Dittmayer, D. E. Yilmaz, I. A. El-Shimy, M. Mülleder, C. Hinze, P. B. Persson, K. Mutig, S. Bachmann

This study compares nephrotoxicity of cyclosporine and tacrolimus in rat kidneys using multiomics and histopathology, revealing distinct damage patterns in glomerular and tubular compartments.

bioRxiv · Apr 5, 2023Pathology

CTLA-4 regulates PD-L1-PD-1 interactions via transendocytosis of CD80

A. Kennedy, M. Robinson, C. Hinze, E. Waters, C. Williams, N. Halliday, S. Dovedi, D. Sansom

The paper investigates how CTLA-4 regulates PD-L1-PD-1 interactions through CD80 transendocytosis, showing that CD80 removal enables PD-L1 recovery and that CTLA-4's cytoplasmic domain is essential for this process.

bioRxiv · Mar 28, 2022 · PreprintImmunology