Author

S. Dovedi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

A. Kennedy· 2 shared B. C. Kennedy· 2 shared C. Hinze· 2 shared C. Willis· 2 shared C. Y. Lee· 2 shared D. R. Withers· 2 shared D. Sansom· 2 shared F. Gaspal· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

A. Kennedy

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Author profile →

5 papers

Recent·Most cited

Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80 / PD-L1 interaction

M. A. Robinson, A. Kennedy, C. T. Orozco, H.-C. Chen, E. A. Waters, D. Giovacchini, K. Yeung, L. Filer, C. Hinze, C. Lloyd, S. Dovedi, D. Sansom

This paper shows that rigid, bivalent CTLA-4 binding to CD80 disrupts the cis CD80/PD-L1 interaction, promoting PD-L1 availability through orientation and cross-linking.

bioRxiv · Apr 19, 2024 · PreprintImmunology

Rapid establishment of a tumor-retained state curtails the contribution of conventional NK cells to anti-tumor immunity in solid cancers

I. W. Dean, C. Y. Lee, Z. K. Tuong, Z. Li, C. A. Tibbitt, C. Willis, F. Gaspal, B. C. Kennedy, V. Matei-Rascu, R. Fiancette, C. Nordenvall, U. Lindforss, S. M. Baker, C. Stockmann, V. Sexl, , D. R. Withers

This study shows that conventional NK cells rapidly lose effector functions upon entering tumors and that IL-15:IL-15Ra complexes can restore their function and tissue-residency.

bioRxiv · Aug 10, 2023Immunology

Time-, tissue- and treatment-associated heterogeneity in tumour-residing migratory DCs

C. Y. Lee, B. C. Kennedy, N. Richoz, I. Dean, Z. K. Tuong, F. Gaspal, Z. Li, C. Willis, T. Hasegawa, S. K. Whiteside, D. A. Posner, G. Carlesso, S. A. Hammond, S. Dovedi, R. Roychoudhuri, , M. R. Clatworthy

This study identifies heterogeneous tumor-residing migratory dendritic cells (mRegDCs) that show distinct transcriptional and functional profiles, impacting anti-tumor immune responses.

bioRxiv · Jul 3, 2023Immunology

Small gene networks can delineate immune cell states and characterize immunotherapy response in melanoma

D. Egan, M. Kreileder, M. Nabhan, L. F. Iglesias-Martinez, S. Dovedi, V. Valge-Archer, A. Grover, R. Wilkinson, T. Slidel, C. Bendtsen, I. Barrett, D. Brennan, W. Kolch, V. Zhernovkov

This paper uses small transcription factor-directed co-expression networks to deconvolute immune cell states from bulk RNA-seq data and characterize immunotherapy response in melanoma.

bioRxiv · Jul 11, 2022Immunology

CTLA-4 regulates PD-L1-PD-1 interactions via transendocytosis of CD80

A. Kennedy, M. Robinson, C. Hinze, E. Waters, C. Williams, N. Halliday, S. Dovedi, D. Sansom

The paper investigates how CTLA-4 regulates PD-L1-PD-1 interactions through CD80 transendocytosis, showing that CD80 removal enables PD-L1 recovery and that CTLA-4's cytoplasmic domain is essential for this process.

bioRxiv · Mar 28, 2022 · PreprintImmunology