Mineralocorticoid receptor-independent activation of ENaC in bile duct ligated mice
X.-P. Wang, S. M. Mutchler, R. Carrisoza-Gaytan, M. Al-bataineh, C. J. Baty, A. Vandevender, P. Srinivasan, R. J. Tan, M. J. Jurczak, L. M. Satlin, O. B. Kashlan
This study shows that bile acid elevation in liver disease activates ENaC and causes fluid retention independently of RAAS, offering new therapeutic targets.
bioRxiv · Sep 19, 2023Physiology