Author

C. J. Caceres

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Organism:mouse· 2 Organism:plant (other)· 2 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1 Assay:metagenomics· 1 Research Focus:phylogenetics / evolution· 1

Frequent Co-Authors

D. R. Perez· 8 shared G. Geiger· 5 shared L. C. Gay· 5 shared S. Carnaccini· 5 shared D. S. Rajao· 4 shared B. Seibert· 3 shared A. L. Vincent Baker· 2 shared B. Cowan· 2 shared

Activity by Year

2021-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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8 shared papersMicrobiology

D. R. Perez

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Author profile →

8 papers

Recent·Most cited

Nucleoprotein reassortment enhanced transmissibility of H3 1990.4.a clade influenza A virus in swine

M. N. Thomas, G. Ciacci Zanella, B. Cowan, C. J. Caceres, D. Rajao, D. R. Perez, P. C. Gauger, A. L. Baker, T. K. Anderson

This study shows that reassorting the nucleoprotein gene in H3 influenza A viruses improved transmissibility in swine, but transmission efficiency depends on multiple genes.

Journal of Virology · Mar 19, 2024Peer-reviewedMicrobiology

FLUAV RAM-IGIP: A modified live influenza virus vaccine that enhances humoral and mucosal responses against influenza

C. J. Caceres, L. C. Gay, A. Jain, T. Mejias, M. Cardenas Perez, B. A. Seibert, F. Faccin, B. Cowan, G. Geiger, A. L. Vincent Baker, S. Carnaccini, D. H. Davies, D. S. Rajao, D. R. Perez

This paper develops a modified live influenza virus vaccine (RAM-IGIP) that enhances humoral and mucosal immunity against influenza, showing complete protection in mice.

bioRxiv · Jan 23, 2024 · PreprintImmunology

Antigenic mapping of the hemagglutinin of the H9 subtype influenza A viruses using sera from Japanese quail (Coturnix c. japonica).

S. Carnaccini, C. J. Caceres, L. C. Gay, L. Ferreri, E. Skepner, D. F. Burke, I. H. Brown, G. Geiger, A. Obadan, D. S. Rajao, N. S. Lewis, D. R. Perez

This study maps the antigenic sites of H9 influenza A virus hemagglutinin using quail sera, identifying key amino acid substitutions that affect antigenic profiles and vaccine efficacy.

bioRxiv · May 18, 2023Microbiology

Characterizing a century of genetic diversity and contemporary antigenic diversity of N1 neuraminidase in IAV from North American swine

D. E. Hufnagel, K. M. Young, Z. Arendsee, L. C. Gay, C. J. Caceres, D. S. Rajao, D. R. Perez, A. L. Vincent Baker, T. K. Anderson

This study characterizes the genetic and antigenic diversity of N1 neuraminidase in IAV from North American swine over a century, identifying clades, reassortment events, and antigenic drift patterns.

bioRxiv · Nov 18, 2022 · PreprintEvolutionary Biology

Epistasis reduces fitness costs of influenza A virus escape from stem-binding antibodies

C.-Y. Lee, C. J. Caceres, G. Geiger, B. Seibert, F. C. Faccin, L. C. Gay, L. M. Ferreri, D. Kaul, J. Wrammert, G. S. Tan, D. R. Perez, A. C. Lowen

This study shows that influenza A virus escape from stem-binding antibodies incurs fitness costs, but epistatic interactions can mitigate these costs in some contexts.

bioRxiv · Jul 14, 2022 · PreprintMicrobiology

Pathobiology and dysbiosis of the respiratory and intestinal microbiota in 14 months old Golden Syrian hamsters infected with SARS-CoV-2

B. Seibert, C. J. Caceres, S. Carnaccini, S. Cardenas-Garcia, L. C. Gay, L. Ortiz, G. Geiger, D. S. de Souza Rajao, E. Ottesen, D. R. Perez

This study investigates SARS-CoV-2 infection in aged Golden Syrian hamsters, revealing microbiome dysbiosis and pathobiological changes similar to severe COVID-19 patients.

bioRxiv · Jul 13, 2022Microbiology

Robustness of the ferret model for influenza risk assessment studies: a cross-laboratory exercise

J. A. Belser, E. H. Lau, W. Barclay, I. G. Barr, H. Chen, R. A. Fouchier, M. Hatta, S. Herfst, Y. Kawaoka, S. S. Lakdawala, L. Y. Y. Lee, G. Neumann, M. Peiris, D. R. Perez, C. J. Russell, , K. M. Septer

This study evaluates the consistency of ferret transmission experiments across laboratories for two H1N1 influenza viruses, finding concordant results and suggesting a minimum of three to five labs for reliable risk assessment.

bioRxiv · Apr 2, 2022Microbiology

Efficacy of GC-376 against SARS-CoV-2 virus infection in the K18 hACE2 transgenic mouse model

C. J. Caceres, S. Cardenas-Garcia, S. Carnaccini, B. Seibert, D. S. Rajao, J. Wang, D. R. Perez

This study evaluates GC-376's in vivo antiviral efficacy against SARS-CoV-2 in K18-hACE2 mice, showing reduced viral loads and inflammation but no improvement in clinical symptoms or survival.

bioRxiv · Jan 27, 2021Microbiology