T. K. Anderson

2018-2019 human seasonal H3N2 influenza A virus spillovers into swine with demonstrated virus transmission in pigs were not sustained in the pig population

The paper shows human seasonal H3N2 influenza A viruses can transmit to pigs but are not sustained in the pig population, with limited spread and transmission observed.

Nucleoprotein reassortment enhanced transmissibility of H3 1990.4.a clade influenza A virus in swine

This study shows that reassorting the nucleoprotein gene in H3 influenza A viruses improved transmissibility in swine, but transmission efficiency depends on multiple genes.

Potential pandemic risk of circulating swine H1N2 influenza viruses

The paper assesses the pandemic risk of swine H1N2 influenza viruses by analyzing their transmission potential and immune response in ferrets.

Antigenic and genetic diversity of H1 and H3 influenza A viruses in swine in Brazil

This study characterizes the genetic and antigenic diversity of H1 and H3 influenza A viruses in Brazilian swine from 2010-2018, identifying distinct lineages and antigenic variation with implications for vaccine development.

An alphacoronavirus polymerase structure reveals conserved co-factor functions

This paper determines the structure of an alphacoronavirus polymerase complex and identifies conserved cofactor interactions important for antiviral drug development.

Reverse-zoonoses of 2009 H1N1 pandemic influenza A viruses and evolution in United States swine results in viruses with zoonotic potential

This study shows that pdm09 H1N1 influenza viruses from humans can persist in swine, evolve, and transmit back to humans, increasing pandemic risk.

Characterizing a century of genetic diversity and contemporary antigenic diversity of N1 neuraminidase in IAV from North American swine

This study characterizes the genetic and antigenic diversity of N1 neuraminidase in IAV from North American swine over a century, identifying clades, reassortment events, and antigenic drift patterns.

Interspecies transmission from pigs to ferrets of antigenically distinct swine H1 influenza A viruses with loss in reactivity to human vaccine virus antisera as measures of relative zoonotic risk

The paper assesses the zoonotic risk of swine H1 influenza A viruses by evaluating their cross-reactivity to human vaccine antisera and transmission efficiency in a pig-to-ferret model.

PARNAS: Objectively Selecting the Most Representative Taxa on a Phylogeny

PARNAS selects representative taxa from large phylogenies to cover diversity efficiently, applied to influenza A virus data to inform vaccine design.

Antigenic characterization and pandemic risk assessment of North American H1 influenza A viruses circulating in swine

This study assesses the antigenic and genetic diversity of swine H1 influenza A viruses in North America to evaluate pandemic risk.

Genetic and antigenic characterization of an expanding H3 influenza A virus clade in US swine visualized by Nextstrain

The paper tracks the resurgence of H3 influenza A virus clade C-IVA in US swine, identifying genetic and antigenic factors linked to its increased detection frequency.

pH-dependent polymorphism of the structure of SARS-CoV-2 nsp7

This study determines the solution structure of SARS-CoV-2 nsp7 at pH 7.0 using NMR spectroscopy and identifies pH-dependent structural changes in the protein.

RF-Net 2: Fast Inference of Virus Reassortment and Hybridization Networks

RF-Net 2 improves virus reassortment and hybridization network inference by handling more reticulations and providing error correction, validated on influenza A virus data.

Coordinated evolution between N2 neuraminidase and H1 and H3 hemagglutinin genes increased influenza A virus genetic diversity in swine

A Library of Nucleotide Analogues Terminate RNA Synthesis Catalyzed by Polymerases of Coronaviruses Causing SARS and COVID-19

This paper evaluates nucleotide analogues as inhibitors of SARS-CoV and SARS-CoV-2 RdRp, identifying those that terminate RNA synthesis and resist viral exonuclease activity.

Triphosphates of the Two Components in DESCOVY and TRUVADA are Inhibitors of the SARS-CoV-2 Polymerase

The paper shows that the triphosphates of tenofovir and emtricitabine inhibit SARS-CoV-2 RNA-dependent RNA polymerase, suggesting potential use of DESCOVY and TRUVADA as PrEP for COVID-19.

Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase

This study shows that three nucleotide analogues inhibit SARS-CoV-2 polymerase by being incorporated and blocking further RNA synthesis.

Life-cycle mediated effects of urbanization on parasite communities in the estuarine fish, Fundulus heteroclitus

This study shows urbanization affects parasite communities in estuarine fish by altering physicochemical factors and landscape structure, with greater impacts on indirect life-cycle parasites.

Robinson-Foulds Reticulation Networks

This paper introduces RF-Net, a method to reconstruct reticulation networks from error-prone input trees, demonstrating its ability to identify reassortment in influenza A viruses.

Mitigating Pandemic Risk with Influenza A Virus Field Surveillance at a Swine-Human Interface

The paper describes using field-derived nanopore sequencing to identify a novel swine influenza A virus that posed a pandemic risk, leading to the development of a vaccine candidate and real-time public health response.