D. R. Perez

Nucleoprotein reassortment enhanced transmissibility of H3 1990.4.a clade influenza A virus in swine

This study shows that reassorting the nucleoprotein gene in H3 influenza A viruses improved transmissibility in swine, but transmission efficiency depends on multiple genes.

FLUAV RAM-IGIP: A modified live influenza virus vaccine that enhances humoral and mucosal responses against influenza

This paper develops a modified live influenza virus vaccine (RAM-IGIP) that enhances humoral and mucosal immunity against influenza, showing complete protection in mice.

Swine influenza A virus isolates containing the pandemic H1N1 origin matrix gene elicit greater disease in the murine model

This study shows that swine influenza A viruses with the pandemic H1N1 origin matrix gene cause more severe disease in mice compared to those with the classical swine matrix gene.

Antigenic mapping of the hemagglutinin of the H9 subtype influenza A viruses using sera from Japanese quail (Coturnix c. japonica).

This study maps the antigenic sites of H9 influenza A virus hemagglutinin using quail sera, identifying key amino acid substitutions that affect antigenic profiles and vaccine efficacy.

Characterizing a century of genetic diversity and contemporary antigenic diversity of N1 neuraminidase in IAV from North American swine

This study characterizes the genetic and antigenic diversity of N1 neuraminidase in IAV from North American swine over a century, identifying clades, reassortment events, and antigenic drift patterns.

Independent evolution of influenza A virus H1N1 in pigs in Guatemala

The paper identifies independent evolution of H1N1 influenza A viruses in Guatemalan pigs, showing distinct amino acid signatures and genetic lineage from other Central American H1N1 pdm09 viruses.

Epistasis reduces fitness costs of influenza A virus escape from stem-binding antibodies

This study shows that influenza A virus escape from stem-binding antibodies incurs fitness costs, but epistatic interactions can mitigate these costs in some contexts.

Pathobiology and dysbiosis of the respiratory and intestinal microbiota in 14 months old Golden Syrian hamsters infected with SARS-CoV-2

This study investigates SARS-CoV-2 infection in aged Golden Syrian hamsters, revealing microbiome dysbiosis and pathobiological changes similar to severe COVID-19 patients.

Few amino acid mutations in H6 influenza A virus from South American lineage increase pathogenicity in poultry

The study shows that serial passage of a South American lineage H6N2 influenza A virus in chickens leads to 13 amino acid mutations, some in HA and NA, which increase viral shedding but not transmission.

Transmission of human influenza A virus in pigs selects for adaptive mutations on the HA gene

This study shows that human-origin influenza A viruses can transmit in pigs and select for adaptive mutations in the HA gene that improve replication and fitness in swine hosts.

Robustness of the ferret model for influenza risk assessment studies: a cross-laboratory exercise

This study evaluates the consistency of ferret transmission experiments across laboratories for two H1N1 influenza viruses, finding concordant results and suggesting a minimum of three to five labs for reliable risk assessment.

Influenza A virus reassortment in mammals gives rise to genetically distinct within-host sub-populations

This study examines reassortment dynamics of influenza A virus in guinea pigs, ferrets, and swine, finding reassortment is common but more frequent in ferrets and guinea pigs than swine, with spatial compartmentalization observed.

Mild and severe SARS-CoV-2 infection induces respiratory and intestinal microbiome changes in the K18-hACE2 transgenic mouse model

This study examines microbiome changes in K18-hACE2 mice infected with SARS-CoV-2 at different doses, finding reduced diversity and specific taxonomic shifts in the cecum but not the lung.

Efficacy of GC-376 against SARS-CoV-2 virus infection in the K18 hACE2 transgenic mouse model

This study evaluates GC-376's in vivo antiviral efficacy against SARS-CoV-2 in K18-hACE2 mice, showing reduced viral loads and inflammation but no improvement in clinical symptoms or survival.

Collective interactions augment influenza A virus replication in a host-dependent manner

The paper shows that influenza A virus requires collective interactions for replication in mammalian cells but not in avian cells, with the PA gene segment playing a key role.

The pneumococcal two-component system VisRH is linked to enhanced intracellular survival of Streptococcus pneumoniae in influenza-infected pneumocytes

This study identifies the VisRH two-component system in Streptococcus pneumoniae as critical for enhanced intracellular survival in influenza-infected pneumocytes through stress response gene regulation.