G. S. Tan

Epistasis reduces fitness costs of influenza A virus escape from stem-binding antibodies

This study shows that influenza A virus escape from stem-binding antibodies incurs fitness costs, but epistatic interactions can mitigate these costs in some contexts.

Persistent Immune and Clotting Dysfunction Detected in Saliva and Blood Plasma after COVID-19

The paper identifies persistent immune and clotting dysfunction in saliva and plasma of COVID-19 patients 4-6 weeks post-symptom resolution, highlighting saliva as a viable alternative to plasma for monitoring immune and inflammatory sequelae.

A Herpes Simplex Virus Type-1-derived influenza vaccine induces balanced adaptive immune responses and protects mice from lethal influenza virus challenge.

Structurally and functionally distinct early antibody responses predict COVID-19 disease trajectory and mRNA vaccine response

The paper identifies early antibody responses that predict COVID-19 severity and vaccine response, showing functional differences in inflammation regulation.

Collective interactions augment influenza A virus replication in a host-dependent manner

The paper shows that influenza A virus requires collective interactions for replication in mammalian cells but not in avian cells, with the PA gene segment playing a key role.

The Dynamics of Influenza A H3N2 Defective Viral Genomes from a Human Challenge Study

This study analyzes defective viral genomes (DVGs) in longitudinal human challenge studies of influenza A H3N2, finding genetic drift drives their evolution rather than selection.

Microbiome disturbance and resilience dynamics of the upper respiratory tract in response to influenza A virus infection in analog hosts

The paper examines how influenza A virus infection affects the upper respiratory tract microbiome in humans and ferrets, finding that infected individuals experience microbiome disturbances that recover over time.